@article{bbe2e221d1174c249de80edaf3ff57b9,
title = "Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls",
abstract = "To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6–8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06–1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66–1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59–0.91]); the three p-trends were <0.05. Menarche differed by 4–7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.",
keywords = "Environmental, Menarche, Phenols, Phthalates, Phytoestrogens",
author = "Wolff, {Mary S.} and Ashley Pajak and Pinney, {Susan M.} and Windham, {Gayle C.} and Maida Galvez and Michael Rybak and Silva, {Manori J.} and Xiaoyun Ye and Calafat, {Antonia M.} and Kushi, {Lawrence H.} and Biro, {Frank M.} and Teitelbaum, {Susan L.}",
note = "Funding Information: This research was supported by the Breast Cancer and the Environment Research Program (BCERP) award numbers U01ES012770, U01ES012771, U01ES012800, U01ES012801, U01ES019435, U01ES019453, U01ES019454, U01ES019457, and by R827039, P01ES009584, P30ES006096, P30ES023515 from the National Institute of Environmental Health Sciences (NIEHS) , the National Cancer Institute (NCI) , EPA, NIH, DHHS, CSTA-UL1RR029887, NYS Empire Clinical Research Investigator Program, Pediatric Environmental Health Fellowship HD049311, and the Avon Foundation. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS or NCI, the National Institutes of Health, the Centers for Disease Control and Prevention, or the California Department of Public Health. Dr. Lawrence H. Kushi is employed by Kaiser Permanente. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2017",
month = jan,
day = "1",
doi = "10.1016/j.reprotox.2016.11.009",
language = "English",
volume = "67",
pages = "56--64",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier Inc.",
}