TY - JOUR
T1 - Associations of hemoglobin A1c with cognition reduced for long diabetes duration
AU - Silverman, Jeremy M.
AU - Schmeidler, James
AU - Lee, Pearl G.
AU - Alexander, Neil B.
AU - Beeri, Michal Schnaider
AU - Guerrero-Berroa, Elizabeth
AU - West, Rebecca K.
AU - Sano, Mary
AU - Nabozny, Martina
AU - Rodriguez Alvarez, Carolina
N1 - Funding Information:
This study was supported by the United States Department of Veterans Affairs (grant numbers I01CX000900 and I01HX000828 ).
Funding Information:
This study was supported by the United States Department of Veterans Affairs (grant numbers I01CX000900 and I01HX000828).
Publisher Copyright:
© 2019
PY - 2019
Y1 - 2019
N2 - Introduction: Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration. Methods: The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young-old” veterans (mean age = 70) with type 2 diabetes. Results: The predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory. Discussion: Findings extend the Protected Survivor Model to a “young-old” sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.
AB - Introduction: Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration. Methods: The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young-old” veterans (mean age = 70) with type 2 diabetes. Results: The predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory. Discussion: Findings extend the Protected Survivor Model to a “young-old” sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.
KW - Cognitive function
KW - Diabetes duration
KW - Hemoglobin A1c
KW - Protected survivor
KW - Protective factors
KW - Risk factors
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85076108775&partnerID=8YFLogxK
U2 - 10.1016/j.trci.2019.11.009
DO - 10.1016/j.trci.2019.11.009
M3 - Article
AN - SCOPUS:85076108775
SN - 2352-8737
VL - 5
SP - 926
EP - 932
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
ER -