Associations between acute and chronic lifetime stressors and psychosis-risk symptoms in individuals with 22q11.2 copy number variants

Jasmine Modasi, Vahe Khachadourian, Kathleen O'Hora, Leila Kushan, George M. Slavich, Grant S. Shields, Eva Velthorst, Carrie E. Bearden

Research output: Contribution to journalArticlepeer-review

Abstract

Background The 22q11.2 deletion (22q11Del) is among the strongest known genetic risk factors for psychosis. Stress, a known risk factor for psychosis in the general population, has seldom been studied in 22q11Del. We investigated how lifetime stressors related to symptomatic outcomes in patients with 22q11Del. We also explored this association in individuals with 22q11.2 duplications (22q11Dup), which may be potentially protective against psychosis. Method One hundred individuals (46 with 22q11Del, 30 with 22q11Dup, and 24 healthy controls; Mage = 17.30 years±10.15) were included.

Original languageEnglish
Pages (from-to)7222-7231
Number of pages10
JournalPsychological Medicine
Volume53
Issue number15
DOIs
StatePublished - 20 Nov 2023

Keywords

  • 22q11.2
  • Acute stress
  • chronic stress
  • copy number variant
  • environmental risk factors
  • psychosis

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