TY - JOUR
T1 - Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension
AU - García-Álvarez, Ana
AU - García-Lunar, Inés
AU - Pereda, Daniel
AU - Fernández-Jimenez, Rodrigo
AU - Sánchez-González, Javier
AU - Mirelis, Jesús G.
AU - Nuño-Ayala, Mario
AU - Sánchez-Quintana, Damian
AU - Fernández-Friera, Leticia
AU - García-Ruiz, Jose M.
AU - Pizarro, Gonzalo
AU - Agüero, Jaume
AU - Campelos, Paula
AU - Castellá, Manuel
AU - Sabaté, Manel
AU - Fuster, Valentin
AU - Sanz, Javier
AU - Ibañez, Borja
N1 - Funding Information:
This study was partly funded by the “ Red de Investigación Cardiovascular ” (RIC) of the Spanish Ministry of Health ( RD 12/0042/0054 to Dr. Ibáñez) and by ISCIII “ Fondo de Investigación Sanitaria ” grant PI13 /02339 to Dr. García-Álvarez. Drs. García-Álvarez, Mirelis, Fernández-Friera, Pizarro, and Ibáñez are members of different institutions participating in the RIC. Other sponsors were the Spanish Heart Foundation (basic research project 2012 to Dr. García-Álvarez) and a master research agreement between Philips Healthcare and CNIC. All authors have reported that they have no relationships relevant to the contents of this paper to disclose. The first 2 authors contributed equally to this work. Raymond Kwong, MD, MPH, has served as Guest Editor for this paper.
Publisher Copyright:
© 2015 by the American College of Cardiology Foundation.
PY - 2015
Y1 - 2015
N2 - Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.
AB - Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.
KW - Equilibrium contrast
KW - Extracellular volume
KW - Magnetic resonance
KW - Native T1
KW - Pulmonary hypertension
KW - T1 mapping
UR - http://www.scopus.com/inward/record.url?scp=84922547399&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2014.08.012
DO - 10.1016/j.jcmg.2014.08.012
M3 - Review article
C2 - 25592698
AN - SCOPUS:84922547399
SN - 1936-878X
VL - 8
SP - 76
EP - 82
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 1
ER -