Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension

Ana García-Álvarez, Inés García-Lunar, Daniel Pereda, Rodrigo Fernández-Jimenez, Javier Sánchez-González, Jesús G. Mirelis, Mario Nuño-Ayala, Damian Sánchez-Quintana, Leticia Fernández-Friera, Jose M. García-Ruiz, Gonzalo Pizarro, Jaume Agüero, Paula Campelos, Manuel Castellá, Manel Sabaté, Valentin Fuster, Javier Sanz, Borja Ibañez

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalJACC: Cardiovascular Imaging
Volume8
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Equilibrium contrast
  • Extracellular volume
  • Magnetic resonance
  • Native T1
  • Pulmonary hypertension
  • T1 mapping

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