Association of lower urinary tract symptoms and the metabolic syndrome: Results from the boston area community health survey

Varant Kupelian, Kevin T. McVary, Steven A. Kaplan, Susan A. Hall, Carol L. Link, Lalitha Padmanabhan Aiyer, Patrick Mollon, Nihad Tamimi, Raymond C. Rosen, John B. McKinlay

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Purpose: In this study we investigated the relationship between lower urinary tract symptoms as defined by the American Urological Association symptom index and the metabolic syndrome, and determined the relationship between individual symptoms comprising the American Urological Association symptom index and the metabolic syndrome. Materials and Methods: The Boston Area Community Health Survey used a 2-stage cluster design to recruit a random sample of 2,301 men 30 to 79 years old. Analyses were conducted on 1,899 men who provided blood samples. Urological symptoms comprising the American Urological Association symptom index were included in the analysis. The metabolic syndrome was defined using a modification of the Adult Treatment Panel III guidelines. The association between lower urinary tract symptoms and the metabolic syndrome was assessed using odds ratios and 95% confidence intervals estimated using logistic regression models. Results: Increased odds of the metabolic syndrome were observed in men with mild to severe symptoms (American Urological Association symptom index 2 to 35) compared to those with an American Urological Association symptom index score of 0 or 1 (multivariate OR 1.68, 95% CI 1.21-2.35). A statistically significant association was observed between the metabolic syndrome and a voiding symptom score of 5 or greater (multivariate adjusted OR 1.73, 95% CI 1.06-2.80) but not for a storage symptom score of 4 or greater (multivariate adjusted OR 0.94, 95% CI 0.66-1.33). Increased odds of the metabolic syndrome were observed even with mild symptoms, primarily for incomplete emptying, intermittency and nocturia. These associations were observed primarily in younger men (younger than 60 years) and were null in older men (60 years old or older). Conclusions: The observed association between urological symptoms and the metabolic syndrome provides further evidence of common underlying factors between lower urinary tract symptoms and chronic conditions outside the urinary tract.

Original languageEnglish
Pages (from-to)S107-S115
JournalJournal of Urology
Volume189
Issue number1 SUPPL
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • epidemiology
  • metabolic syndrome X
  • signs and symptoms
  • urinary tract

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