TY - JOUR
T1 - Association of human immunodeficiency virus infection and autoimmune phenomena
AU - Kopelman, Rima G.
AU - Zolla-Pazner, Susan
N1 - Funding Information:
From the Division of Rheumatology, Department of Medicine, Columbia Presbyterian Medical Center, New York, New York; Laboratory Service, New York Veteran’s Administration Medical Center, and Department of Pathology, New York University Medical Center, New York, New York. This work was supported in part by funding from the National Institutes of Health (Al-62542 and Al-72658) by a grant from the New York State AIDS Institute, and by research funds from the Veteran’s Administration. This work was presented in abstract form at the Northeastern Regional Meeting of the American Rheumatism Association, October 1986, and the American Rheumatism Association National Meeting, June 1987. Requests for reprints should be addressed to Dr. Rima Kopelman, 630 West 168th Street, New York, New York 10032. Manuscript submitted May 4, 1987, and accepted in revised form October 2, 1987.
PY - 1988/1
Y1 - 1988/1
N2 - Patients infected with human immunodeficiency virus have a variety of presentations including fevers, lymphadenopathy, rash, renal dysfunction, and neurologic and hematologic disorders. Many of these features are also seen in patients with systemic lupus erythematosus (SLE). Herein are described five patients ultimately diagnosed as having acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) in whom the differential diagnosis included SLE because of multi-system disease and autoimmune phenomena, especially positive antinuclear antibodies. Serum samples from 151 consecutive patients with AIDS or ARC were examined and 19 with low titer-positive antinuclear antibodies were found (17 at 1:20 and two at 1:160). These observations suggest that SLE and human immunodeficiency virus infection may share clinical and serologic features.
AB - Patients infected with human immunodeficiency virus have a variety of presentations including fevers, lymphadenopathy, rash, renal dysfunction, and neurologic and hematologic disorders. Many of these features are also seen in patients with systemic lupus erythematosus (SLE). Herein are described five patients ultimately diagnosed as having acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) in whom the differential diagnosis included SLE because of multi-system disease and autoimmune phenomena, especially positive antinuclear antibodies. Serum samples from 151 consecutive patients with AIDS or ARC were examined and 19 with low titer-positive antinuclear antibodies were found (17 at 1:20 and two at 1:160). These observations suggest that SLE and human immunodeficiency virus infection may share clinical and serologic features.
UR - https://www.scopus.com/pages/publications/0023912169
U2 - 10.1016/0002-9343(88)90012-5
DO - 10.1016/0002-9343(88)90012-5
M3 - Article
C2 - 3257353
AN - SCOPUS:0023912169
SN - 0002-9343
VL - 84
SP - 82
EP - 88
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 1
ER -