TY - JOUR
T1 - Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population
AU - Nagrani, Rajini
AU - Mhatre, Sharayu
AU - Rajaraman, Preetha
AU - Chatterjee, Nilanjan
AU - Akbari, Mohammad R.
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Badwe, Rajendra
AU - Gupta, Sudeep
AU - Dikshit, Rajesh
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/1/18
Y1 - 2017/1/18
N2 - To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.
AB - To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.
UR - http://www.scopus.com/inward/record.url?scp=85010070389&partnerID=8YFLogxK
U2 - 10.1038/srep40963
DO - 10.1038/srep40963
M3 - Article
C2 - 28098224
AN - SCOPUS:85010070389
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
M1 - 40963
ER -