TY - JOUR
T1 - Association of exfoliation syndrome and central retinal vein occlusion
T2 - An ultrastructural analysis
AU - Ritch, Robert
AU - Prata, Tiago S.
AU - De Moraes, Carlos Gustavo V.
AU - Vessani, Roberto M.
AU - Costa, Vital P.
AU - Konstas, Anastasios G.P.
AU - Liebmann, Jeffrey M.
AU - Schlötzer-Schrehardt, Ursula
PY - 2010/2
Y1 - 2010/2
N2 - Purpose: To evaluate prospectively the frequency with which exfoliation syndrome (XFS) occurs in patients with central retinal vein occlusion (CRVO) by clinical examination and ultrastructural examination of conjunctival biopsy specimens. Methods: Prospective observational case series. Thirty-six eyes of 36 consecutive patients with CRVO were investigated for XFS by slit-lamp examination and conjunctival biopsy when XFS was not clinically visible on examination. Results: A clinical diagnosis of XFS or a positive biopsy result for exfoliation material (XFM) was present in 22 of the 36 patients (61%; 95% confidence interval 45-75%). Twelve of these 22 patients (54%) had a clinical diagnosis of XFS. Aggregates of XFM were identified ultrastructurally in the biopsy specimens in 10 of 24 patients with no clinical signs of XFS (42%). Patients with and without XFS had similar distribution of age, gender, race and prevalence of systemic disorders. Twelve of the 22 (54%) XFS patients had neither glaucoma nor ocular hypertension prior to the CRVO. Conclusion: In accordance with previous retrospective and histological studies, this prospective, in vivo study suggests that CRVO is commonly associated with XFS.
AB - Purpose: To evaluate prospectively the frequency with which exfoliation syndrome (XFS) occurs in patients with central retinal vein occlusion (CRVO) by clinical examination and ultrastructural examination of conjunctival biopsy specimens. Methods: Prospective observational case series. Thirty-six eyes of 36 consecutive patients with CRVO were investigated for XFS by slit-lamp examination and conjunctival biopsy when XFS was not clinically visible on examination. Results: A clinical diagnosis of XFS or a positive biopsy result for exfoliation material (XFM) was present in 22 of the 36 patients (61%; 95% confidence interval 45-75%). Twelve of these 22 patients (54%) had a clinical diagnosis of XFS. Aggregates of XFM were identified ultrastructurally in the biopsy specimens in 10 of 24 patients with no clinical signs of XFS (42%). Patients with and without XFS had similar distribution of age, gender, race and prevalence of systemic disorders. Twelve of the 22 (54%) XFS patients had neither glaucoma nor ocular hypertension prior to the CRVO. Conclusion: In accordance with previous retrospective and histological studies, this prospective, in vivo study suggests that CRVO is commonly associated with XFS.
KW - Central retinal vein occlusion
KW - Conjunctival biopsy
KW - Exfoliation syndrome
UR - https://www.scopus.com/pages/publications/76149133076
U2 - 10.1111/j.1755-3768.2009.01578.x
DO - 10.1111/j.1755-3768.2009.01578.x
M3 - Article
C2 - 19725816
AN - SCOPUS:76149133076
SN - 1755-375X
VL - 88
SP - 91
EP - 95
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 1
ER -