Association of Epstein–Barr Virus with Thymic Carcinoma

Serge Leyvraz; Werner Henle; A. Philippe Chahinian; Catharina Perlmann; George Klein; Ronald E. Gordon; Marc Rosenblum; James F. Holland

doi:10.1056/NEJM198505163122006

Association of Epstein–Barr Virus with Thymic Carcinoma

Serge Leyvraz
, Werner Henle
, A. Philippe Chahinian
, Catharina Perlmann
, George Klein
, Ronald E. Gordon
, Marc Rosenblum
, James F. Holland

Research output: Contribution to journal › Article › peer-review

250 Scopus citations

Abstract

The Epstein–Barr virus is a ubiquitous B-cell lymphocytotropic virus that is known to cause infectious mononucleosis¹ and lymphoproliferative disorders in immunodeficient patients² and has been implicated in the genesis of Burkitt's lymphoma³ and primary intracerebral lymphoma.⁴ The association of Epstein–Barr virus with epithelial cells has been more puzzling, but recent studies have shown that the virus can penetrate and replicate in some epithelial cells.⁵ ⁶ ⁷ Undifferentiated nasopharyngeal carcinoma is consistently associated with Epstein–Barr virus.⁸ Another undifferentiated tumor with histopathological characteristics similar to those of undifferentiated nasopharyngeal carcinoma is the lymphoepithelioma-like carcinoma of the thymus. This subtype of thymic carcinomas has a.

Original language	English
Pages (from-to)	1296-1299
Number of pages	4
Journal	New England Journal of Medicine
Volume	312
Issue number	20
DOIs	https://doi.org/10.1056/NEJM198505163122006
State	Published - 16 May 1985
Externally published	Yes

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title = "Association of Epstein{\textendash}Barr Virus with Thymic Carcinoma",

abstract = "The Epstein{\textendash}Barr virus is a ubiquitous B-cell lymphocytotropic virus that is known to cause infectious mononucleosis1 and lymphoproliferative disorders in immunodeficient patients2 and has been implicated in the genesis of Burkitt's lymphoma3 and primary intracerebral lymphoma.4 The association of Epstein{\textendash}Barr virus with epithelial cells has been more puzzling, but recent studies have shown that the virus can penetrate and replicate in some epithelial cells.5 6 7 Undifferentiated nasopharyngeal carcinoma is consistently associated with Epstein{\textendash}Barr virus.8 Another undifferentiated tumor with histopathological characteristics similar to those of undifferentiated nasopharyngeal carcinoma is the lymphoepithelioma-like carcinoma of the thymus. This subtype of thymic carcinomas has a.",

author = "Serge Leyvraz and Werner Henle and Chahinian, \{A. Philippe\} and Catharina Perlmann and George Klein and Gordon, \{Ronald E.\} and Marc Rosenblum and Holland, \{James F.\}",

year = "1985",

month = may,

day = "16",

doi = "10.1056/NEJM198505163122006",

language = "English",

volume = "312",

pages = "1296--1299",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

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TY - JOUR

T1 - Association of Epstein–Barr Virus with Thymic Carcinoma

AU - Leyvraz, Serge

AU - Henle, Werner

AU - Chahinian, A. Philippe

AU - Perlmann, Catharina

AU - Klein, George

AU - Gordon, Ronald E.

AU - Rosenblum, Marc

AU - Holland, James F.

PY - 1985/5/16

Y1 - 1985/5/16

N2 - The Epstein–Barr virus is a ubiquitous B-cell lymphocytotropic virus that is known to cause infectious mononucleosis1 and lymphoproliferative disorders in immunodeficient patients2 and has been implicated in the genesis of Burkitt's lymphoma3 and primary intracerebral lymphoma.4 The association of Epstein–Barr virus with epithelial cells has been more puzzling, but recent studies have shown that the virus can penetrate and replicate in some epithelial cells.5 6 7 Undifferentiated nasopharyngeal carcinoma is consistently associated with Epstein–Barr virus.8 Another undifferentiated tumor with histopathological characteristics similar to those of undifferentiated nasopharyngeal carcinoma is the lymphoepithelioma-like carcinoma of the thymus. This subtype of thymic carcinomas has a.

AB - The Epstein–Barr virus is a ubiquitous B-cell lymphocytotropic virus that is known to cause infectious mononucleosis1 and lymphoproliferative disorders in immunodeficient patients2 and has been implicated in the genesis of Burkitt's lymphoma3 and primary intracerebral lymphoma.4 The association of Epstein–Barr virus with epithelial cells has been more puzzling, but recent studies have shown that the virus can penetrate and replicate in some epithelial cells.5 6 7 Undifferentiated nasopharyngeal carcinoma is consistently associated with Epstein–Barr virus.8 Another undifferentiated tumor with histopathological characteristics similar to those of undifferentiated nasopharyngeal carcinoma is the lymphoepithelioma-like carcinoma of the thymus. This subtype of thymic carcinomas has a.

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U2 - 10.1056/NEJM198505163122006

DO - 10.1056/NEJM198505163122006

M3 - Article

AN - SCOPUS:0022259730

SN - 0028-4793

VL - 312

SP - 1296

EP - 1299

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 20

ER -

Association of Epstein–Barr Virus with Thymic Carcinoma

Abstract

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