Association of elevated α1-antichymotrypsin with cognitive impairment in a prospective study of the very old

Steven M. Gabriel; Deborah B. Marin; Paul S. Aisen; Melinda Lantz; Larry D. Altstiel; Kenneth L. Davis; Richard C. Mohs

doi:10.1176/ajp.155.5.698

Association of elevated α₁-antichymotrypsin with cognitive impairment in a prospective study of the very old

Steven M. Gabriel, Deborah B. Marin, Paul S. Aisen, Melinda Lantz, Larry D. Altstiel, Kenneth L. Davis, Richard C. Mohs

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective: The authors investigated the relationships between concentrations of two acute-phase proteins, α₁-antichymotrypsin (ACT) and α₂-macroglobulin (MAC), and cognitive impairment in the very old. Method: Concentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State. Results: Concentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC. Conclusions: These data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response.

Original language	English
Pages (from-to)	698-700
Number of pages	3
Journal	American Journal of Psychiatry
Volume	155
Issue number	5
DOIs	https://doi.org/10.1176/ajp.155.5.698
State	Published - 1998

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title = "Association of elevated α1-antichymotrypsin with cognitive impairment in a prospective study of the very old",

abstract = "Objective: The authors investigated the relationships between concentrations of two acute-phase proteins, α1-antichymotrypsin (ACT) and α2-macroglobulin (MAC), and cognitive impairment in the very old. Method: Concentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State. Results: Concentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC. Conclusions: These data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response.",

author = "Gabriel, {Steven M.} and Marin, {Deborah B.} and Aisen, {Paul S.} and Melinda Lantz and Altstiel, {Larry D.} and Davis, {Kenneth L.} and Mohs, {Richard C.}",

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T1 - Association of elevated α1-antichymotrypsin with cognitive impairment in a prospective study of the very old

AU - Gabriel, Steven M.

AU - Marin, Deborah B.

AU - Aisen, Paul S.

AU - Lantz, Melinda

AU - Altstiel, Larry D.

AU - Davis, Kenneth L.

AU - Mohs, Richard C.

PY - 1998

Y1 - 1998

N2 - Objective: The authors investigated the relationships between concentrations of two acute-phase proteins, α1-antichymotrypsin (ACT) and α2-macroglobulin (MAC), and cognitive impairment in the very old. Method: Concentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State. Results: Concentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC. Conclusions: These data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response.

AB - Objective: The authors investigated the relationships between concentrations of two acute-phase proteins, α1-antichymotrypsin (ACT) and α2-macroglobulin (MAC), and cognitive impairment in the very old. Method: Concentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State. Results: Concentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC. Conclusions: These data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response.

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Association of elevated α1-antichymotrypsin with cognitive impairment in a prospective study of the very old

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Association of elevated α₁-antichymotrypsin with cognitive impairment in a prospective study of the very old