TY - JOUR
T1 - Association of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicity
AU - Langs-Barlow, Allison
AU - Selvaraj, Shanmugapriya
AU - Ogbuagu, Onyema
AU - Shabanova, Veronika
AU - Shapiro, Eugene D.
AU - Paintsil, Elijah
N1 - Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [K08AI074404 to EP].
Publisher Copyright:
© 2014 Elsevier B.V. and Mitochondria Research Society.
PY - 2015/1
Y1 - 2015/1
N2 - Diagnosis of antiretroviral therapy (ART) toxicity is complicated. Apoptosis has been implicated in ART toxicity. Cytochrome c (Cyt-C) is a mitochondrial protein found in plasma during pro-apoptotic states. We conducted a study of HIV-infected individuals on ART with (cases, n= 21) and without (controls, n= 21) clinical evidence of toxicity to determine if elevated plasma Cyt-C is associated with ART toxicity. When corrected for CD4 count, viral load, and duration of HIV infection, cases are 7.86 times more likely than controls to have plasma Cyt-C. >. 0.216 ng/mL. Cyt-C could be a useful clinical tool to guide treatment decisions in this population.
AB - Diagnosis of antiretroviral therapy (ART) toxicity is complicated. Apoptosis has been implicated in ART toxicity. Cytochrome c (Cyt-C) is a mitochondrial protein found in plasma during pro-apoptotic states. We conducted a study of HIV-infected individuals on ART with (cases, n= 21) and without (controls, n= 21) clinical evidence of toxicity to determine if elevated plasma Cyt-C is associated with ART toxicity. When corrected for CD4 count, viral load, and duration of HIV infection, cases are 7.86 times more likely than controls to have plasma Cyt-C. >. 0.216 ng/mL. Cyt-C could be a useful clinical tool to guide treatment decisions in this population.
KW - Antiretroviral therapy
KW - Cytochrome c
KW - Mitochondrial toxicity
UR - http://www.scopus.com/inward/record.url?scp=84918547550&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2014.11.004
DO - 10.1016/j.mito.2014.11.004
M3 - Article
C2 - 25435346
AN - SCOPUS:84918547550
SN - 1567-7249
VL - 20
SP - 71
EP - 74
JO - Mitochondrion
JF - Mitochondrion
ER -