@article{af5280cf780446a6a2bd1f6d9fe5ef09,
title = "Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence",
abstract = "The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.",
keywords = "Association analyses, CHRM2, Cognitive ability, Genetics, IQ, Intelligence",
author = "Dick, {Danielle M.} and Fazil Aliev and John Kramer and Wang, {Jen C.} and Anthony Hinrichs and Sarah Bertelsen and Sam Kuperman and Marc Schuckit and John Nurnberger and Edenberg, {Howard J.} and Bernice Porjesz and Henri Begleiter and Victor Hesselbrock and Alison Goate and Laura Bierut",
note = "Funding Information: Acknowledgments The Collaborative Study on the Genetics of Alcoholism (COGA), Co-Principal Investigators B. Porjesz, V. Hesselbrock, H. Edenberg, L. Bierut, includes nine different centers where data collection, analysis, and storage take place. The nine sites and Principal Investigators and Co-Investigators are: University of Connecticut (V. Hesselbrock); Indiana University (H.J. Edenberg, J. Nurnberger Jr., P.M. Conneally, T. Foroud); University of Iowa (S. Kuperman, R. Crowe); SUNY Downstate (B. Porjesz); Washington University in St. Louis (L. Bierut, A. Goate, J. Rice); University of California at San Diego (M. Schuckit); Howard University (R. Taylor); Rutgers University (J. Tischfield); Southwest Foundation (L. Almasy). Zhaoxia Ren serves as the NIAAA Staff Collaborator. This national collaborative study is supported by the NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).",
year = "2007",
month = mar,
doi = "10.1007/s10519-006-9131-2",
language = "English",
volume = "37",
pages = "265--272",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer",
number = "2",
}