TY - JOUR
T1 - Association of apolipoprotein E-e4 and dementia declines with age
AU - Valerio, Daniel
AU - Raventos, Henriette
AU - Schmeidler, James
AU - Beeri, Michal S.
AU - Villalobos, Lara Mora
AU - Bolaños-Palmieri, Patricia
AU - Carrión-Baralt, José R.
AU - Fornaguera, Jaime
AU - Silverman, Jeremy M.
N1 - Funding Information:
This study was funded by a NIH Fogarty International Center & National Institute on Aging grant ( R21TW009258 ), the Universidad de Costa Rica , and the Alzheimer's Association .
Publisher Copyright:
© 2014 American Association for Geriatric Psychiatry.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). Methods In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years. Results Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact. Conclusions The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.
AB - Objective To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). Methods In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years. Results Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact. Conclusions The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.
KW - Successful cognitive aging oldest-old dementia risk factors
UR - http://www.scopus.com/inward/record.url?scp=84925326574&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2014.03.008
DO - 10.1016/j.jagp.2014.03.008
M3 - Article
C2 - 24731780
AN - SCOPUS:84925326574
SN - 1064-7481
VL - 22
SP - 957
EP - 960
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 10
ER -