Association of apolipoprotein E-e4 and dementia declines with age

Daniel Valerio, Henriette Raventos, James Schmeidler, Michal S. Beeri, Lara Mora Villalobos, Patricia Bolaños-Palmieri, José R. Carrión-Baralt, Jaime Fornaguera, Jeremy M. Silverman

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14 Scopus citations


Objective To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). Methods In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years. Results Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact. Conclusions The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.

Original languageEnglish
Pages (from-to)957-960
Number of pages4
JournalAmerican Journal of Geriatric Psychiatry
Issue number10
StatePublished - 1 Oct 2014


  • Successful cognitive aging oldest-old dementia risk factors


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