Association of alirocumab therapy with inflammatory lesions of the vocal folds: A case report

Peter A. Benedict; Rania M. Abdou; Gregory R. Dion; Peak Woo; Ryan C. Branski; Milan R. Amin

doi:10.1002/lary.26426

Association of alirocumab therapy with inflammatory lesions of the vocal folds: A case report

Peter A. Benedict
, Rania M. Abdou
, Gregory R. Dion
, Peak Woo
, Ryan C. Branski
, Milan R. Amin

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side-effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation. Laryngoscope, 127:1652–1654, 2017.

Original language	English
Pages (from-to)	1652-1654
Number of pages	3
Journal	Laryngoscope
Volume	127
Issue number	7
DOIs	https://doi.org/10.1002/lary.26426
State	Published - Jul 2017

Keywords

Larynx
adverse effect
alirocumab
laryngeal lesion
monoclonal antibody

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10.1002/lary.26426

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title = "Association of alirocumab therapy with inflammatory lesions of the vocal folds: A case report",

abstract = "Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side-effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation. Laryngoscope, 127:1652–1654, 2017.",

keywords = "Larynx, adverse effect, alirocumab, laryngeal lesion, monoclonal antibody",

author = "Benedict, \{Peter A.\} and Abdou, \{Rania M.\} and Dion, \{Gregory R.\} and Peak Woo and Branski, \{Ryan C.\} and Amin, \{Milan R.\}",

note = "Publisher Copyright: {\textcopyright} 2016 The American Laryngological, Rhinological and Otological Society, Inc.",

year = "2017",

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doi = "10.1002/lary.26426",

language = "English",

volume = "127",

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T2 - A case report

AU - Benedict, Peter A.

AU - Abdou, Rania M.

AU - Dion, Gregory R.

AU - Woo, Peak

AU - Branski, Ryan C.

AU - Amin, Milan R.

PY - 2017/7

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N2 - Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side-effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation. Laryngoscope, 127:1652–1654, 2017.

AB - Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side-effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation. Laryngoscope, 127:1652–1654, 2017.

KW - Larynx

KW - adverse effect

KW - alirocumab

KW - laryngeal lesion

KW - monoclonal antibody

UR - https://www.scopus.com/pages/publications/85006786160

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SP - 1652

EP - 1654

JO - Laryngoscope

JF - Laryngoscope

IS - 7

ER -

Association of alirocumab therapy with inflammatory lesions of the vocal folds: A case report

Abstract

Keywords

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