Association of Age With 10-Year Outcomes After Coronary Surgery in the Arterial Revascularization Trial

Mario Gaudino, Antonino Di Franco, Marcus Flather, Stephen Gerry, Emilia Bagiella, Alastair Gray, Leon Pearcey, Teng Hui Saw, Belinda Lees, Umberto Benedetto, Stephen E. Fremes, David P. Taggart

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17 Scopus citations


Background: The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined. Objectives: The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial. Methods: The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used. Results: Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03). Conclusions: Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalJournal of the American College of Cardiology
Issue number1
StatePublished - 5 Jan 2021


  • CABG
  • bilateral internal thoracic arteries
  • single internal thoracic artery


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