Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

Yonghong Li; Kristina Tacey; Lisa Doil; Ryan Van Luchene; Veronica Garcia; Charles Rowland; Steve Schrodi; Diane Leong; Kit Lau; Joe Catanese; John Sninsky; Petra Nowotny; Peter Holmans; John Hardy; John Powell; Simon Lovestone; Leon Thal; Michael Owen; Julie Williams; Alison Goate; Andrew Grupe

doi:10.1016/j.neulet.2004.05.047

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

Yonghong Li
, Kristina Tacey
, Lisa Doil
, Ryan Van Luchene
, Veronica Garcia
, Charles Rowland
, Steve Schrodi
, Diane Leong
, Kit Lau
, Joe Catanese
, John Sninsky
, Petra Nowotny
, Peter Holmans
, John Hardy
, John Powell
, Simon Lovestone
, Leon Thal
, Michael Owen
, Julie Williams
, Alison Goate

Andrew Grupe

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Neuroscience Letters
Volume	366
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2004.05.047
State	Published - 19 Aug 2004
Externally published	Yes

Keywords

ABCA1
ATP-binding cassette A1 transporter
Alzheimer's disease
polymorphism

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10.1016/j.neulet.2004.05.047

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Li, Y., Tacey, K., Doil, L., Luchene, R. V., Garcia, V., Rowland, C., Schrodi, S., Leong, D., Lau, K., Catanese, J., Sninsky, J., Nowotny, P., Holmans, P., Hardy, J., Powell, J., Lovestone, S., Thal, L., Owen, M., Williams, J., ... Grupe, A. (2004). Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neuroscience Letters, 366(3), 268-271. https://doi.org/10.1016/j.neulet.2004.05.047

@article{2ccdd4ea6e46495495ab8335668cb37f,

title = "Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study",

abstract = "Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.",

keywords = "ABCA1, ATP-binding cassette A1 transporter, Alzheimer's disease, polymorphism",

author = "Yonghong Li and Kristina Tacey and Lisa Doil and Luchene, \{Ryan Van\} and Veronica Garcia and Charles Rowland and Steve Schrodi and Diane Leong and Kit Lau and Joe Catanese and John Sninsky and Petra Nowotny and Peter Holmans and John Hardy and John Powell and Simon Lovestone and Leon Thal and Michael Owen and Julie Williams and Alison Goate and Andrew Grupe",

note = "Funding Information: We thank the families for their participation in this study and our colleagues at Celera Diagnostics, particularly Daniel Civello, for providing expert technical support. Funding for this work was provided by NIH (AG16208, AG05681), the MRC, UK (J.W., M.O., S.L., and J.P.), the Alzheimer{\textquoteright}s Research Trust (J.W., M.O., and S.L.), and ADRC grant P 50 AG0 5131 (L.T.). J.H. was supported by the NIA intramural program and he would like to thank the Verum Foundation.",

year = "2004",

month = aug,

day = "19",

doi = "10.1016/j.neulet.2004.05.047",

language = "English",

volume = "366",

pages = "268--271",

journal = "Neuroscience Letters",

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Li, Y, Tacey, K, Doil, L, Luchene, RV, Garcia, V, Rowland, C, Schrodi, S, Leong, D, Lau, K, Catanese, J, Sninsky, J, Nowotny, P, Holmans, P, Hardy, J, Powell, J, Lovestone, S, Thal, L, Owen, M, Williams, J, Goate, A & Grupe, A 2004, 'Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study', Neuroscience Letters, vol. 366, no. 3, pp. 268-271. https://doi.org/10.1016/j.neulet.2004.05.047

TY - JOUR

T1 - Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

AU - Li, Yonghong

AU - Tacey, Kristina

AU - Doil, Lisa

AU - Luchene, Ryan Van

AU - Garcia, Veronica

AU - Rowland, Charles

AU - Schrodi, Steve

AU - Leong, Diane

AU - Lau, Kit

AU - Catanese, Joe

AU - Sninsky, John

AU - Nowotny, Petra

AU - Holmans, Peter

AU - Hardy, John

AU - Powell, John

AU - Lovestone, Simon

AU - Thal, Leon

AU - Owen, Michael

AU - Williams, Julie

AU - Goate, Alison

AU - Grupe, Andrew

N1 - Funding Information: We thank the families for their participation in this study and our colleagues at Celera Diagnostics, particularly Daniel Civello, for providing expert technical support. Funding for this work was provided by NIH (AG16208, AG05681), the MRC, UK (J.W., M.O., S.L., and J.P.), the Alzheimer’s Research Trust (J.W., M.O., and S.L.), and ADRC grant P 50 AG0 5131 (L.T.). J.H. was supported by the NIA intramural program and he would like to thank the Verum Foundation.

PY - 2004/8/19

Y1 - 2004/8/19

N2 - Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.

AB - Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.

KW - ABCA1

KW - ATP-binding cassette A1 transporter

KW - Alzheimer's disease

KW - polymorphism

UR - https://www.scopus.com/pages/publications/3543119039

U2 - 10.1016/j.neulet.2004.05.047

DO - 10.1016/j.neulet.2004.05.047

M3 - Article

C2 - 15288432

AN - SCOPUS:3543119039

SN - 0304-3940

VL - 366

SP - 268

EP - 271

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

Abstract

Keywords

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