Association between prenatal exposure to metals and neonatal morbidity

Isabella Karakis, Batia Sarov, Daniella Landau, Esther Manor, Maayan Yitshak-Sade, Michal Rotenberg, Reli Hershkovitz, Itamar Grotto, Elena Gurevich, Lena Novack

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value =.052), (3) neonates that weighed less (p value =.079), and (4) in women who experienced repeated abortions (p value =.049). Our findings suggest the possibility of metal-induced oxidative stress.

Original languageEnglish
Pages (from-to)1281-1284
Number of pages4
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Issue number21
StatePublished - 26 Nov 2014
Externally publishedYes


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