TY - JOUR
T1 - Association between personal exposure to ambient metals and respiratory disease in Italian adolescents
T2 - A cross-sectional study
AU - Rosa, Maria José
AU - Benedetti, Chiara
AU - Peli, Marco
AU - Donna, Filippo
AU - Nazzaro, Marco
AU - Fedrighi, Chiara
AU - Zoni, Silvia
AU - Marcon, Alessandro
AU - Zimmerman, Neil
AU - Wright, Rosalind
AU - Lucchini, Roberto
N1 - Funding Information:
The authors would like to thank the participating parents and children. This study was supported by funding from the European Union through the Sixth Framework Programme for RTD (contract # FOOD-CT-2006-016253). It reflects only the authors’ views, and the European Commission is not liable for any use that may be made of the information contained therein. The project was supported also by Award Number R01ES019222 from the National Institute of Environmental Health Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences or the National Institutes of Health.
Publisher Copyright:
© 2016 Rosa et al.
PY - 2016/1/12
Y1 - 2016/1/12
N2 - Background: Release of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity. Methods: As part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11-14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has historic ferroalloy activity and Garda Lake which has no history of ferroalloy activity. Particulate matter <10μm in diameter (PM10) was collected for 24h in filters using personal sampling. Mn, nickel (Ni), zinc (Zn), chromium (Cr) and iron (Fe) were measured in filters using x-ray fluorescence. Data on respiratory health was collected through questionnaire. Data for 280 adolescents were analyzed using a modified Poisson regression, and risk ratios were calculated for an interquartile (IQR) range increase in each pollutant. Results: In adjusted models including PM10 as a co-pollutant, we found significant associations between concentrations of Mn (RR: 1.09, 95% CI [1.00, 1.18] per 42ng/m3 increase), Ni (RR: 1.11, 95% CI [1.03, 1.21] per 4ng/m3 increase) and Cr (RR: 1.08, 95% CI [1.06, 1.11] per 9ng/m3 increase) and parental report of asthma. We also found significant associations between increased Mn and Ni and increased risk of asthma medication use in the past 12months (RR: 1.13, 95% CI [1.04, 1.29] and (RR: 1.13, 95 % CI [1.01, 1.27] respectively). Conclusions: Our findings suggest that exposure to ambient Mn, Ni and Cr may be associated with adverse respiratory outcomes.
AB - Background: Release of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity. Methods: As part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11-14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has historic ferroalloy activity and Garda Lake which has no history of ferroalloy activity. Particulate matter <10μm in diameter (PM10) was collected for 24h in filters using personal sampling. Mn, nickel (Ni), zinc (Zn), chromium (Cr) and iron (Fe) were measured in filters using x-ray fluorescence. Data on respiratory health was collected through questionnaire. Data for 280 adolescents were analyzed using a modified Poisson regression, and risk ratios were calculated for an interquartile (IQR) range increase in each pollutant. Results: In adjusted models including PM10 as a co-pollutant, we found significant associations between concentrations of Mn (RR: 1.09, 95% CI [1.00, 1.18] per 42ng/m3 increase), Ni (RR: 1.11, 95% CI [1.03, 1.21] per 4ng/m3 increase) and Cr (RR: 1.08, 95% CI [1.06, 1.11] per 9ng/m3 increase) and parental report of asthma. We also found significant associations between increased Mn and Ni and increased risk of asthma medication use in the past 12months (RR: 1.13, 95% CI [1.04, 1.29] and (RR: 1.13, 95 % CI [1.01, 1.27] respectively). Conclusions: Our findings suggest that exposure to ambient Mn, Ni and Cr may be associated with adverse respiratory outcomes.
KW - Adolescent health
KW - Air pollution
KW - Asthma
KW - Metal
KW - Personal monitoring
UR - http://www.scopus.com/inward/record.url?scp=84953878147&partnerID=8YFLogxK
U2 - 10.1186/s12890-016-0173-9
DO - 10.1186/s12890-016-0173-9
M3 - Article
C2 - 26754125
AN - SCOPUS:84953878147
SN - 1471-2466
VL - 16
JO - BMC Pulmonary Medicine
JF - BMC Pulmonary Medicine
IS - 1
M1 - 6
ER -