Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

Ronald M. Adkins; John N. Fain; Julia Krushkal; Chad K. Klauser; Everett F. Magann; John C. Morrison

doi:10.1203/PDR.0b013e3181425841

Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

Ronald M. Adkins
, John N. Fain
, Julia Krushkal
, Chad K. Klauser
, Everett F. Magann
, John C. Morrison

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5′ end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.

Original language	English
Pages (from-to)	451-455
Number of pages	5
Journal	Pediatric Research
Volume	62
Issue number	4
DOIs	https://doi.org/10.1203/PDR.0b013e3181425841
State	Published - Oct 2007
Externally published	Yes

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title = "Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels",

abstract = "The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5′ end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.",

author = "Adkins, \{Ronald M.\} and Fain, \{John N.\} and Julia Krushkal and Klauser, \{Chad K.\} and Magann, \{Everett F.\} and Morrison, \{John C.\}",

year = "2007",

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doi = "10.1203/PDR.0b013e3181425841",

language = "English",

volume = "62",

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journal = "Pediatric Research",

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TY - JOUR

T1 - Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

AU - Adkins, Ronald M.

AU - Fain, John N.

AU - Krushkal, Julia

AU - Klauser, Chad K.

AU - Magann, Everett F.

AU - Morrison, John C.

PY - 2007/10

Y1 - 2007/10

N2 - The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5′ end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.

AB - The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5′ end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.

UR - https://www.scopus.com/pages/publications/34748925916

U2 - 10.1203/PDR.0b013e3181425841

DO - 10.1203/PDR.0b013e3181425841

M3 - Article

C2 - 17667841

AN - SCOPUS:34748925916

SN - 0031-3998

VL - 62

SP - 451

EP - 455

JO - Pediatric Research

JF - Pediatric Research

IS - 4

ER -

Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

Abstract

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