Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

Ronald M. Adkins, John N. Fain, Julia Krushkal, Chad K. Klauser, Everett F. Magann, John C. Morrison

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5′ end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalPediatric Research
Volume62
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

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