Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene

Enrique Baca-Garcia, Concepcion Vaquero-Lorenzo, Montserrat Diaz-Hernandez, Beatriz Rodriguez-Salgado, Helen Dolengevich-Segal, Manuel Arrojo-Romero, Carlota Botillo-Martin, Antonio Ceverino, Jose Fernandez Piqueras, M. Mercedes Perez-Rodriguez, Jeronimo Saiz-Ruiz

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background: Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD. Methods: The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians. Results: Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls. Conclusions: Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume31
Issue number2
DOIs
StatePublished - 30 Mar 2007
Externally publishedYes

Keywords

  • Genetic polymorphism
  • Intron 2
  • Obsessive-compulsive disorder
  • Serotonin transporter
  • Variable number tandem repeats

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