TY - JOUR
T1 - Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene
AU - Baca-Garcia, Enrique
AU - Vaquero-Lorenzo, Concepcion
AU - Diaz-Hernandez, Montserrat
AU - Rodriguez-Salgado, Beatriz
AU - Dolengevich-Segal, Helen
AU - Arrojo-Romero, Manuel
AU - Botillo-Martin, Carlota
AU - Ceverino, Antonio
AU - Piqueras, Jose Fernandez
AU - Perez-Rodriguez, M. Mercedes
AU - Saiz-Ruiz, Jeronimo
PY - 2007/3/30
Y1 - 2007/3/30
N2 - Background: Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD. Methods: The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians. Results: Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls. Conclusions: Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
AB - Background: Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD. Methods: The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians. Results: Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls. Conclusions: Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
KW - Genetic polymorphism
KW - Intron 2
KW - Obsessive-compulsive disorder
KW - Serotonin transporter
KW - Variable number tandem repeats
UR - http://www.scopus.com/inward/record.url?scp=33846820262&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2006.10.016
DO - 10.1016/j.pnpbp.2006.10.016
M3 - Article
C2 - 17174018
AN - SCOPUS:33846820262
SN - 0278-5846
VL - 31
SP - 416
EP - 420
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 2
ER -