TY - JOUR
T1 - Association between nutrient intake and peripheral artery disease
T2 - Results from the InCHIANTI study
AU - Antonelli-Incalzi, Raffaele
AU - Pedone, Claudio
AU - McDermott, Mary M.
AU - Bandinelli, Stefania
AU - Miniati, Benedetta
AU - Lova, Raffaele Molino
AU - Lauretani, Fulvio
AU - Ferrucci, Luigi
N1 - Funding Information:
The InCHIANTI project was supported as a targeted project by the Italian Ministry of Health (ICS110.1/R597.71).
PY - 2006/5
Y1 - 2006/5
N2 - Background: Little is known about the relationship between dietary patterns and peripheral arterial disease (PAD). Our aim was to estimate the association between nutrient intake and diagnosis of PAD. Methods and results: We assessed the nutrient intake of 1251 home-dwelling subjects enrolled in the InCHIANTI study, mean age 68 years (S.D.: 15). We explored the relationship between nutrient intake, obtained through the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire, and PAD, defined as an ankle-brachial index (ABI) < 0.90. After adjustment for potential confounders, we found a reduction of the risk of having an ABI < 0.90 associated with vegetable lipid intake ≥ 34.4 g/day (OR: 0.39; 95% CI: 0.16-0.97), Vitamin E intake ≥ 7.726 mg/day (OR: 0.37; 95% CI 0.16-0.84) and higher serum HDL cholesterol concentration (OR: 0.76; 95% CI: 0.63-0.92 for 10 mg/dl increase). Age (OR: 1.11; 95% CI 1.07-1.14 for 1 year increase), smoking (OR: 1.03; 95% CI: 1.01-1.04 for 10 packs/year increase) and pulse pressure (OR: 1.11; 95% CI: 1.03-1.19 for 5 mmHg increase) were associated with an increased risk of PAD. Conclusions: A higher intake of vegetable lipids, Vitamin E and higher concentrations of serum HDL cholesterol characterize subjects free from PAD. Prospective studies are needed to verify whether this dietary pattern and/or interventions aimed at increasing HDL cholesterol exert some protective effect against PAD.
AB - Background: Little is known about the relationship between dietary patterns and peripheral arterial disease (PAD). Our aim was to estimate the association between nutrient intake and diagnosis of PAD. Methods and results: We assessed the nutrient intake of 1251 home-dwelling subjects enrolled in the InCHIANTI study, mean age 68 years (S.D.: 15). We explored the relationship between nutrient intake, obtained through the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire, and PAD, defined as an ankle-brachial index (ABI) < 0.90. After adjustment for potential confounders, we found a reduction of the risk of having an ABI < 0.90 associated with vegetable lipid intake ≥ 34.4 g/day (OR: 0.39; 95% CI: 0.16-0.97), Vitamin E intake ≥ 7.726 mg/day (OR: 0.37; 95% CI 0.16-0.84) and higher serum HDL cholesterol concentration (OR: 0.76; 95% CI: 0.63-0.92 for 10 mg/dl increase). Age (OR: 1.11; 95% CI 1.07-1.14 for 1 year increase), smoking (OR: 1.03; 95% CI: 1.01-1.04 for 10 packs/year increase) and pulse pressure (OR: 1.11; 95% CI: 1.03-1.19 for 5 mmHg increase) were associated with an increased risk of PAD. Conclusions: A higher intake of vegetable lipids, Vitamin E and higher concentrations of serum HDL cholesterol characterize subjects free from PAD. Prospective studies are needed to verify whether this dietary pattern and/or interventions aimed at increasing HDL cholesterol exert some protective effect against PAD.
KW - Aging
KW - Epidemiology
KW - Nutrition
KW - Peripheral artery disease
KW - Peripheral vascular disease
UR - http://www.scopus.com/inward/record.url?scp=33645851638&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2005.07.016
DO - 10.1016/j.atherosclerosis.2005.07.016
M3 - Article
C2 - 16112120
AN - SCOPUS:33645851638
SN - 0021-9150
VL - 186
SP - 200
EP - 206
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -