Association between nitrated lipoproteins and vascular function in type 2 diabetes

Ajibola Adedayo; Ayobami Eluwole; Fasika Tedla; Arye Kremer; Nicole Mastrogiovanni; Muhammad Khan; Carl Rosenberg; Paul Dreizen; John La Rosa; Louis Salciccioli; Mohamed Boutjdir; Mary Ann Banerji; Clinton Brown; Moro Salifu; Jason Lazar; Ahmed Bakillah

doi:10.2741/4910

Association between nitrated lipoproteins and vascular function in type 2 diabetes

Ajibola Adedayo, Ayobami Eluwole, Fasika Tedla, Arye Kremer, Nicole Mastrogiovanni, Muhammad Khan, Carl Rosenberg, Paul Dreizen, John La Rosa, Louis Salciccioli, Mohamed Boutjdir, Mary Ann Banerji, Clinton Brown, Moro Salifu, Jason Lazar, Ahmed Bakillah

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.

Original language	English
Pages (from-to)	644-663
Number of pages	20
Journal	Frontiers in Bioscience - Landmark
Volume	26
Issue number	4
DOIs	https://doi.org/10.2741/4910
State	Published - 1 Jan 2021
Externally published	Yes

Keywords

African-Americans
Biomarkers
Cardiovascular Disease
Endothelium Function
Lipoproteins
Myeloperoxidase
Nitration
Nitric Oxide
Type 2 diabetes
Vascular Complications

Access to Document

10.2741/4910

Cite this

Adedayo, A., Eluwole, A., Tedla, F., Kremer, A., Mastrogiovanni, N., Khan, M., Rosenberg, C., Dreizen, P., La Rosa, J., Salciccioli, L., Boutjdir, M., Banerji, M. A., Brown, C., Salifu, M., Lazar, J., & Bakillah, A. (2021). Association between nitrated lipoproteins and vascular function in type 2 diabetes. Frontiers in Bioscience - Landmark, 26(4), 644-663. https://doi.org/10.2741/4910

@article{9270fda190d14caf8feca1be2186a880,

title = "Association between nitrated lipoproteins and vascular function in type 2 diabetes",

abstract = "Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0\% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0\% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.",

keywords = "African-Americans, Biomarkers, Cardiovascular Disease, Endothelium Function, Lipoproteins, Myeloperoxidase, Nitration, Nitric Oxide, Type 2 diabetes, Vascular Complications",

author = "Ajibola Adedayo and Ayobami Eluwole and Fasika Tedla and Arye Kremer and Nicole Mastrogiovanni and Muhammad Khan and Carl Rosenberg and Paul Dreizen and \{La Rosa\}, John and Louis Salciccioli and Mohamed Boutjdir and Banerji, \{Mary Ann\} and Clinton Brown and Moro Salifu and Jason Lazar and Ahmed Bakillah",

year = "2021",

month = jan,

day = "1",

doi = "10.2741/4910",

language = "English",

volume = "26",

pages = "644--663",

journal = "Frontiers in Bioscience - Landmark",

issn = "2768-6701",

publisher = "IMR Press Limited",

number = "4",

}

Adedayo, A, Eluwole, A, Tedla, F, Kremer, A, Mastrogiovanni, N, Khan, M, Rosenberg, C, Dreizen, P, La Rosa, J, Salciccioli, L, Boutjdir, M, Banerji, MA, Brown, C, Salifu, M, Lazar, J & Bakillah, A 2021, 'Association between nitrated lipoproteins and vascular function in type 2 diabetes', Frontiers in Bioscience - Landmark, vol. 26, no. 4, pp. 644-663. https://doi.org/10.2741/4910

TY - JOUR

T1 - Association between nitrated lipoproteins and vascular function in type 2 diabetes

AU - Adedayo, Ajibola

AU - Eluwole, Ayobami

AU - Tedla, Fasika

AU - Kremer, Arye

AU - Mastrogiovanni, Nicole

AU - Khan, Muhammad

AU - Rosenberg, Carl

AU - Dreizen, Paul

AU - La Rosa, John

AU - Salciccioli, Louis

AU - Boutjdir, Mohamed

AU - Banerji, Mary Ann

AU - Brown, Clinton

AU - Salifu, Moro

AU - Lazar, Jason

AU - Bakillah, Ahmed

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.

AB - Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.

KW - African-Americans

KW - Biomarkers

KW - Cardiovascular Disease

KW - Endothelium Function

KW - Lipoproteins

KW - Myeloperoxidase

KW - Nitration

KW - Nitric Oxide

KW - Type 2 diabetes

KW - Vascular Complications

UR - https://www.scopus.com/pages/publications/85092887303

U2 - 10.2741/4910

DO - 10.2741/4910

M3 - Article

C2 - 33049686

AN - SCOPUS:85092887303

SN - 2768-6701

VL - 26

SP - 644

EP - 663

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

IS - 4

ER -

Association between nitrated lipoproteins and vascular function in type 2 diabetes

Abstract

Keywords

Access to Document

Fingerprint

Cite this