TY - JOUR
T1 - Association between fetal growth restriction and maternal exposure to polybrominated diphenyl ethers
AU - Jin, Yuting
AU - Li, Jialin
AU - Deng, Xiaokai
AU - Xia, Bin
AU - Song, Qi
AU - Zhao, Yingya
AU - He, Xiaoxiao
AU - Li, Yimei
AU - Xu, Zhangye
AU - Xie, Ailan
AU - Lin, Jing
AU - Zhang, Yunhui
AU - Chen, Shangqin
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/15
Y1 - 2020/7/15
N2 - Humans are exposed to polybrominated diphenyl ethers (PBDEs) via ingestion of food, dust inhalation, and dermal absorption. Exposure to PBDEs via the placenta and breast milk is a special and important pathway in infants. This nested case-control study aimed to investigate the levels of PBDEs in maternal serum and colostrum, and to assess the association between the occurrence of fetal growth restriction (FGR) and prenatal exposure to PBDEs. We recruited 293 mother-newborn pairs, including 98 FGR cases and 195 healthy controls in Wenzhou, China. Maternal serum and colostrum samples were collected during pregnancy and after delivery, respectively, and the levels of PBDEs were measured by gas chromatography-tandem mass spectrometry. The total levels of PBDEs in maternal serum and colostrum were found to be in equilibrium, but congener profiles of PBDEs in these matrices were different. Increased BDE-207, BDE-209, ∑BDE196-209 and ∑PBDEs levels in maternal serum and BDE-99, ∑BDE17-154 and ∑PBDEs levels in colostrum were correlated with decreased birth weight Z score. Increased concentrations of higher brominated BDEs in maternal serum (odds ratio (OR) = 1.010, 95%CI = 1.003–1.018) and low-to moderately brominated BDEs in colostrum (OR = 1.004, 95%CI = 1.000–1.009) were associated with increased risk of FGR, which showed an exposure–response relationship. In addition, infants with FGR were more exposed to PBDEs in colostrum after birth than healthy infants. Longitudinal birth cohort studies are needed to determine the prolonged effect of PBDEs exposure on the growth of FGR infants in the future.
AB - Humans are exposed to polybrominated diphenyl ethers (PBDEs) via ingestion of food, dust inhalation, and dermal absorption. Exposure to PBDEs via the placenta and breast milk is a special and important pathway in infants. This nested case-control study aimed to investigate the levels of PBDEs in maternal serum and colostrum, and to assess the association between the occurrence of fetal growth restriction (FGR) and prenatal exposure to PBDEs. We recruited 293 mother-newborn pairs, including 98 FGR cases and 195 healthy controls in Wenzhou, China. Maternal serum and colostrum samples were collected during pregnancy and after delivery, respectively, and the levels of PBDEs were measured by gas chromatography-tandem mass spectrometry. The total levels of PBDEs in maternal serum and colostrum were found to be in equilibrium, but congener profiles of PBDEs in these matrices were different. Increased BDE-207, BDE-209, ∑BDE196-209 and ∑PBDEs levels in maternal serum and BDE-99, ∑BDE17-154 and ∑PBDEs levels in colostrum were correlated with decreased birth weight Z score. Increased concentrations of higher brominated BDEs in maternal serum (odds ratio (OR) = 1.010, 95%CI = 1.003–1.018) and low-to moderately brominated BDEs in colostrum (OR = 1.004, 95%CI = 1.000–1.009) were associated with increased risk of FGR, which showed an exposure–response relationship. In addition, infants with FGR were more exposed to PBDEs in colostrum after birth than healthy infants. Longitudinal birth cohort studies are needed to determine the prolonged effect of PBDEs exposure on the growth of FGR infants in the future.
KW - Colostrum
KW - Fetal growth restriction
KW - Gestational exposure
KW - Lactational exposure
KW - Maternal serum
KW - Polybrominated diphenyl ethers
UR - http://www.scopus.com/inward/record.url?scp=85083767272&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2020.110623
DO - 10.1016/j.ecoenv.2020.110623
M3 - Article
C2 - 32361490
AN - SCOPUS:85083767272
SN - 0147-6513
VL - 198
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
M1 - 110623
ER -