Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

Rie Kishida; Xin Yin; Sarah Krull Abe; Md Shafiur Rahman; Eiko Saito; Md Rashedul Islam; Qing Lan; Batel Blechter; Nathaniel Rothman; Norie Sawada; Akiko Tamakoshi; Xiao Ou Shu; Atsushi Hozawa; Seiki Kanemura; Jeongseon Kim; Yumi Sugawara; Sue K. Park; Sun Seog Kweon; Habibul Ahsan; Paolo Boffetta; Kee Seng Chia; Keitaro Matsuo; You Lin Qiao; Wei Zheng; Manami Inoue; Daehee Kang; Wei Jie Seow

doi:10.1002/ijc.35191

Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

Rie Kishida, Xin Yin, Sarah Krull Abe, Md Shafiur Rahman, Eiko Saito, Md Rashedul Islam, Qing Lan, Batel Blechter, Nathaniel Rothman, Norie Sawada, Akiko Tamakoshi, Xiao Ou Shu, Atsushi Hozawa, Seiki Kanemura, Jeongseon Kim, Yumi Sugawara, Sue K. Park, Sun Seog Kweon, Habibul Ahsan, Paolo BoffettaKee Seng Chia, Keitaro Matsuo, You Lin Qiao, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow

Research output: Contribution to journal › Article › peer-review

Abstract

Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30–1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26–1.66 in men; HR = 1.47, 95% CI = 1.22–1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18–1.73 in never-smokers; HR = 1.46, 95% CI =1.27–1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36–1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46–2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02–3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

Original language	English
Journal	International Journal of Cancer
DOIs	https://doi.org/10.1002/ijc.35191
State	Accepted/In press - 2024
Externally published	Yes

Keywords

Asia
cohort consortium
family history
lung cancer

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10.1002/ijc.35191

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Kishida, R., Yin, X., Abe, S. K., Rahman, M. S., Saito, E., Islam, M. R., Lan, Q., Blechter, B., Rothman, N., Sawada, N., Tamakoshi, A., Shu, X. O., Hozawa, A., Kanemura, S., Kim, J., Sugawara, Y., Park, S. K., Kweon, S. S., Ahsan, H., ... Seow, W. J. (Accepted/In press). Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal of Cancer. https://doi.org/10.1002/ijc.35191

@article{3010e33c13004bdca5b7a54e898299f9,

title = "Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium",

abstract = "Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30–1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26–1.66 in men; HR = 1.47, 95% CI = 1.22–1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18–1.73 in never-smokers; HR = 1.46, 95% CI =1.27–1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36–1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46–2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02–3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.",

keywords = "Asia, cohort consortium, family history, lung cancer",

author = "Rie Kishida and Xin Yin and Abe, {Sarah Krull} and Rahman, {Md Shafiur} and Eiko Saito and Islam, {Md Rashedul} and Qing Lan and Batel Blechter and Nathaniel Rothman and Norie Sawada and Akiko Tamakoshi and Shu, {Xiao Ou} and Atsushi Hozawa and Seiki Kanemura and Jeongseon Kim and Yumi Sugawara and Park, {Sue K.} and Kweon, {Sun Seog} and Habibul Ahsan and Paolo Boffetta and Chia, {Kee Seng} and Keitaro Matsuo and Qiao, {You Lin} and Wei Zheng and Manami Inoue and Daehee Kang and Seow, {Wei Jie}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.",

year = "2024",

doi = "10.1002/ijc.35191",

language = "English",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

}

Kishida, R, Yin, X, Abe, SK, Rahman, MS, Saito, E, Islam, MR, Lan, Q, Blechter, B, Rothman, N, Sawada, N, Tamakoshi, A, Shu, XO, Hozawa, A, Kanemura, S, Kim, J, Sugawara, Y, Park, SK, Kweon, SS, Ahsan, H, Boffetta, P, Chia, KS, Matsuo, K, Qiao, YL, Zheng, W, Inoue, M, Kang, D & Seow, WJ 2024, 'Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium', International Journal of Cancer. https://doi.org/10.1002/ijc.35191

TY - JOUR

T1 - Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

AU - Kishida, Rie

AU - Yin, Xin

AU - Abe, Sarah Krull

AU - Rahman, Md Shafiur

AU - Saito, Eiko

AU - Islam, Md Rashedul

AU - Lan, Qing

AU - Blechter, Batel

AU - Rothman, Nathaniel

AU - Sawada, Norie

AU - Tamakoshi, Akiko

AU - Shu, Xiao Ou

AU - Hozawa, Atsushi

AU - Kanemura, Seiki

AU - Kim, Jeongseon

AU - Sugawara, Yumi

AU - Park, Sue K.

AU - Kweon, Sun Seog

AU - Ahsan, Habibul

AU - Boffetta, Paolo

AU - Chia, Kee Seng

AU - Matsuo, Keitaro

AU - Qiao, You Lin

AU - Zheng, Wei

AU - Inoue, Manami

AU - Kang, Daehee

AU - Seow, Wei Jie

PY - 2024

Y1 - 2024

N2 - Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30–1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26–1.66 in men; HR = 1.47, 95% CI = 1.22–1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18–1.73 in never-smokers; HR = 1.46, 95% CI =1.27–1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36–1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46–2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02–3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

AB - Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30–1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26–1.66 in men; HR = 1.47, 95% CI = 1.22–1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18–1.73 in never-smokers; HR = 1.46, 95% CI =1.27–1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36–1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46–2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02–3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

KW - Asia

KW - cohort consortium

KW - family history

KW - lung cancer

UR - http://www.scopus.com/inward/record.url?scp=85205537390&partnerID=8YFLogxK

U2 - 10.1002/ijc.35191

DO - 10.1002/ijc.35191

M3 - Article

AN - SCOPUS:85205537390

SN - 0020-7136

JO - International Journal of Cancer

JF - International Journal of Cancer

ER -

Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

Abstract

Keywords

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