TY - JOUR
T1 - Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings
AU - Nash, M. W.
AU - Sugden, K.
AU - Huezo-Diaz, P.
AU - Williamson, R.
AU - Sterne, A.
AU - Purcell, S.
AU - Sham, P. C.
AU - Craig, I. W.
PY - 2005/5/5
Y1 - 2005/5/5
N2 - Evidence indicates the genetic susceptibility to depression and anxiety is both overlapping and dimensional. In the current study, a quantitative phenotype had been created from several depression and anxiety-related measures in order to index this common genetic susceptibility (G). This has been studied in 119 sibships comprising 312 individuals, selected for extreme scores on G, from a community-based sample of 34,371 individuals. In a pathway based candidate gene study, we examined five microsatellite markers located within or nearby to five serotonin system genes (5HT2C, 5HT1D, SHT1B, TPH1, and MAOB). Statistical analysis, carried out using QTDT, gave a significant association with a microsatellite downstream of TPH1. Further analysis included a life-events composite as a co-variable, this lead to a stronger association of TPH1. To our knowledge, this is the first study to report an association of the 3′ end of TPH1 with continuous measures of depression and anxiety.
AB - Evidence indicates the genetic susceptibility to depression and anxiety is both overlapping and dimensional. In the current study, a quantitative phenotype had been created from several depression and anxiety-related measures in order to index this common genetic susceptibility (G). This has been studied in 119 sibships comprising 312 individuals, selected for extreme scores on G, from a community-based sample of 34,371 individuals. In a pathway based candidate gene study, we examined five microsatellite markers located within or nearby to five serotonin system genes (5HT2C, 5HT1D, SHT1B, TPH1, and MAOB). Statistical analysis, carried out using QTDT, gave a significant association with a microsatellite downstream of TPH1. Further analysis included a life-events composite as a co-variable, this lead to a stronger association of TPH1. To our knowledge, this is the first study to report an association of the 3′ end of TPH1 with continuous measures of depression and anxiety.
KW - Anxiety
KW - Depression
KW - Neuroticism
KW - Serotonin
KW - Tryptophan hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=17744375972&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.30063
DO - 10.1002/ajmg.b.30063
M3 - Article
C2 - 15729745
AN - SCOPUS:17744375972
SN - 1552-4841
VL - 135 B
SP - 33
EP - 37
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 1
ER -