Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

D. Sieburth; E. W. Jabs; J. A. Warrington; X. Li; J. Lasota; S. LaForgia; K. Kelleher; K. Huebner; J. J. Wasmuth; S. F. Wolf

doi:10.1016/S0888-7543(05)80283-6

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

D. Sieburth, E. W. Jabs, J. A. Warrington, X. Li, J. Lasota, S. LaForgia, K. Kelleher, K. Huebner, J. J. Wasmuth, S. F. Wolf

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

Original language	English
Pages (from-to)	59-62
Number of pages	4
Journal	Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0888-7543(05)80283-6
State	Published - Sep 1992
Externally published	Yes

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@article{74f59f3a384e4638895155c9481f9cbd,

title = "Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5",

abstract = "IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.",

author = "D. Sieburth and Jabs, {E. W.} and Warrington, {J. A.} and X. Li and J. Lasota and S. LaForgia and K. Kelleher and K. Huebner and Wasmuth, {J. J.} and Wolf, {S. F.}",

note = "Funding Information: This work was supported in part by NIH Grant DE10180 and HG00373 to E.W.J. and NIH Grant HG00320 to J.J.W.J.A.W. was supported by Carcinogenesis Training Grant NCI5T32CA09054-17.",

year = "1992",

month = sep,

doi = "10.1016/S0888-7543(05)80283-6",

language = "English",

volume = "14",

pages = "59--62",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

AU - Sieburth, D.

AU - Jabs, E. W.

AU - Warrington, J. A.

AU - Li, X.

AU - Lasota, J.

AU - LaForgia, S.

AU - Kelleher, K.

AU - Huebner, K.

AU - Wasmuth, J. J.

AU - Wolf, S. F.

N1 - Funding Information: This work was supported in part by NIH Grant DE10180 and HG00373 to E.W.J. and NIH Grant HG00320 to J.J.W.J.A.W. was supported by Carcinogenesis Training Grant NCI5T32CA09054-17.

PY - 1992/9

Y1 - 1992/9

N2 - IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

AB - IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

UR - http://www.scopus.com/inward/record.url?scp=0026693587&partnerID=8YFLogxK

U2 - 10.1016/S0888-7543(05)80283-6

DO - 10.1016/S0888-7543(05)80283-6

M3 - Article

C2 - 1358798

AN - SCOPUS:0026693587

SN - 0888-7543

VL - 14

SP - 59

EP - 62

JO - Genomics

JF - Genomics

IS - 1

ER -

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

Abstract

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