Assessment of the neurogenic flare reaction in small-fiber neuropathies

A. Bickel, H. H. Krämer, M. J. Hilz, F. Birklein, B. Neundörfer, M. Schmelz

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


To improve sensitivity of the analysis of axon reflex flare reaction, the authors used a laser Doppler scanner and analyzed flare intensity and size induced by histamine iontophoresis simultaneously at the foot and thigh in patients with small-fiber neuropathy (n = 10) and controls (n = 9). Flare size, but not laser Doppler flux, clearly distinguished patients from controls at both locations (p < 0.01) and may be useful for evaluation of small-fiber neuropathies.

Original languageEnglish
Pages (from-to)917-919
Number of pages3
Issue number6
StatePublished - 24 Sep 2002
Externally publishedYes


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