Assessment of coagulation system activation using spot urine measurements

S. E. Lind, S. Goldshteyn, C. P. Barry, J. R. Lindquist, A. A. Piergies, T. Rosen, J. R. Schneider, D. H. Shevrin, J. A. Caprini

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Coagulation system activation is most commonly assessed by measuring levels of one or more proteins in peripheral blood. Because faulty blood- drawing can cause activation of the coagulation system, artifactual elevations of such markers have been reported. We have therefore investigated the possibility of using randomly collected ('spot') urine samples as a non- invasive means of assessing the state of coagulation system activation. Using a commercially available enzyme-linked immunosorbent assay kit designed to measure plasma levels of fragment 1+ 2, we found immunoreactive fragment 2 in healthy control subjects, and significantly increased levels in diabetic and non-diabetic pregnant subjects, and patients with venous thromboembolism, prostate cancer, and diabetes. Measurements of excretion of immunoreactive fragment 2 are worth further study as an adjunct or alternative to plasma- based assays designed to detect or quantify coagulation system activation.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Issue number5
StatePublished - 1999
Externally publishedYes


  • Blood coagulation
  • Prothrombin
  • Urine


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