Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.

DA Richards; J. Tuckman; BN Prichard

doi:10.1111/j.1365-2125.1976.tb00637.x

Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.

DA Richards, J. Tuckman, BN Prichard

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Abstract

Isoprenaline dose‐response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta‐adrenoceptor sites. Phenylephrine dose‐response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha‐adrenoceptor sites. The ratio of alpha:beta‐adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90‐120 min after administration. 1976 The British Pharmacological Society

Original language	English
Pages (from-to)	849-855
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2125.1976.tb00637.x
State	Published - Oct 1976

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title = "Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.",

abstract = "Isoprenaline dose‐response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta‐adrenoceptor sites. Phenylephrine dose‐response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha‐adrenoceptor sites. The ratio of alpha:beta‐adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90‐120 min after administration. 1976 The British Pharmacological Society",

author = "DA Richards and J. Tuckman and BN Prichard",

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AU - Prichard, BN

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Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.

Abstract

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