Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine

Dennis S. Charney; George R. Heninger; David E. Sternberg

doi:10.1016/0024-3205(82)90444-1

Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine

Dennis S. Charney, George R. Heninger, David E. Sternberg

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Administration of three oral doses of yohimbine (10 mg, 15 mg, 20 mg) to eight healthy subjects resulted in significant increases in plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG). The 15 mg and 20 mg yohimbine doses induced modest increases in systolic blood pressure and autonomic symptoms such as piloerection and rhinorrhea. Marked behavioral effects such as anxiety were not observed. These results indicate that determination of the plasma MHPG response to yohimbine may be of value in assessing α2 adrenergic autoreceptor function in humans.

Original language	English
Pages (from-to)	2033-2041
Number of pages	9
Journal	Life Sciences
Volume	30
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(82)90444-1
State	Published - 7 Jun 1982
Externally published	Yes

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title = "Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine",

abstract = "Administration of three oral doses of yohimbine (10 mg, 15 mg, 20 mg) to eight healthy subjects resulted in significant increases in plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG). The 15 mg and 20 mg yohimbine doses induced modest increases in systolic blood pressure and autonomic symptoms such as piloerection and rhinorrhea. Marked behavioral effects such as anxiety were not observed. These results indicate that determination of the plasma MHPG response to yohimbine may be of value in assessing α2 adrenergic autoreceptor function in humans.",

author = "Charney, \{Dennis S.\} and Heninger, \{George R.\} and Sternberg, \{David E.\}",

note = "Funding Information: This study was supported in part by the State of Connecticut and USPHS Grants MH-25642, MH-14276, I\textasciitilde{}H-30929, and MH-18949. We thank the research nurses of the Clinical Research Unit for their excellent clinical care and symptom ratings. Acknowledgement is also extended to Karen Hafstad, RN, Paul Bellmore, Robert Reynolds, Ellen Glover, Patty Burzynski and Grace Billings for technical and secretarial help.",

year = "1982",

month = jun,

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doi = "10.1016/0024-3205(82)90444-1",

language = "English",

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T1 - Assessment of α2 adrenergic autoreceptor function in humans

T2 - Effects of oral yohimbine

AU - Charney, Dennis S.

AU - Heninger, George R.

AU - Sternberg, David E.

N1 - Funding Information: This study was supported in part by the State of Connecticut and USPHS Grants MH-25642, MH-14276, I~H-30929, and MH-18949. We thank the research nurses of the Clinical Research Unit for their excellent clinical care and symptom ratings. Acknowledgement is also extended to Karen Hafstad, RN, Paul Bellmore, Robert Reynolds, Ellen Glover, Patty Burzynski and Grace Billings for technical and secretarial help.

PY - 1982/6/7

Y1 - 1982/6/7

N2 - Administration of three oral doses of yohimbine (10 mg, 15 mg, 20 mg) to eight healthy subjects resulted in significant increases in plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG). The 15 mg and 20 mg yohimbine doses induced modest increases in systolic blood pressure and autonomic symptoms such as piloerection and rhinorrhea. Marked behavioral effects such as anxiety were not observed. These results indicate that determination of the plasma MHPG response to yohimbine may be of value in assessing α2 adrenergic autoreceptor function in humans.

AB - Administration of three oral doses of yohimbine (10 mg, 15 mg, 20 mg) to eight healthy subjects resulted in significant increases in plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG). The 15 mg and 20 mg yohimbine doses induced modest increases in systolic blood pressure and autonomic symptoms such as piloerection and rhinorrhea. Marked behavioral effects such as anxiety were not observed. These results indicate that determination of the plasma MHPG response to yohimbine may be of value in assessing α2 adrenergic autoreceptor function in humans.

UR - https://www.scopus.com/pages/publications/0020327568

U2 - 10.1016/0024-3205(82)90444-1

DO - 10.1016/0024-3205(82)90444-1

M3 - Article

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SP - 2033

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JO - Life Sciences

JF - Life Sciences

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ER -

Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine

Abstract

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