Assessing the role of gene therapy in the treatment of vascular disease

Peter L. Faries, Frank B. Pomposelli, William C. Quist, Frank W. LoGerfo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Gene transfer holds promise as a therapeutic modality for the treatment of vascular and cardiovascular disease. Initial phase I trials have demonstrated that gene transfer is feasible and is relatively well tolerated in the short term with limited morbidity and no discernable increase in mortality. Important questions remain to be answered regarding the use of gene therapy for cardiovascular disease. Many of these must be addressed by randomized, double-blinded, multicenter clinical trials. Ultimately, the application of gene therapy to cardiovascular disease will depend on the demonstration of clinical outcomes that are superior to those achieved using the current standards of care.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalAnnals of Vascular Surgery
Volume14
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Dive into the research topics of 'Assessing the role of gene therapy in the treatment of vascular disease'. Together they form a unique fingerprint.

Cite this