Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach

M. Went; A. Sud; P. J. Law; D. C. Johnson; N. Weinhold; A. Försti; M. Duin; J. S. Mitchell; B. Chen; R. Kuiper; O. W. Stephens; U. Bertsch; C. Campo; H. Einsele; W. M. Gregory; M. Henrion; J. Hillengass; P. Hoffmann; G. H. Jackson; O. Lenive; J. Nickel; M. M. Nöthen; M. I.da Silva Filho; H. Thomsen; B. A. Walker; A. Broyl; F. E. Davies; C. Langer; M. Hansson; M. Kaiser; P. Sonneveld; H. Goldschmidt; K. Hemminki; B. Nilsson; G. J. Morgan; R. S. Houlston

doi:10.1038/BCJ.2017.48

Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach

M. Went, A. Sud, P. J. Law, D. C. Johnson, N. Weinhold, A. Försti, M. Duin, J. S. Mitchell, B. Chen, R. Kuiper, O. W. Stephens, U. Bertsch, C. Campo, H. Einsele, W. M. Gregory, M. Henrion, J. Hillengass, P. Hoffmann, G. H. Jackson, O. LeniveJ. Nickel, M. M. Nöthen, M. I.da Silva Filho, H. Thomsen, B. A. Walker, A. Broyl, F. E. Davies, C. Langer, M. Hansson, M. Kaiser, P. Sonneveld, H. Goldschmidt, K. Hemminki, B. Nilsson, G. J. Morgan, R. S. Houlston

Research output: Contribution to journal › Letter › peer-review

10 Scopus citations

Original language	English
Article number	e573
Journal	Blood Cancer Journal
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/BCJ.2017.48
State	Published - 2017
Externally published	Yes

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10.1038/BCJ.2017.48

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Went, M., Sud, A., Law, P. J., Johnson, D. C., Weinhold, N., Försti, A., Duin, M., Mitchell, J. S., Chen, B., Kuiper, R., Stephens, O. W., Bertsch, U., Campo, C., Einsele, H., Gregory, W. M., Henrion, M., Hillengass, J., Hoffmann, P., Jackson, G. H., ... Houlston, R. S. (2017). Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach. Blood Cancer Journal, 7(6), Article e573. https://doi.org/10.1038/BCJ.2017.48

@article{8b7440a2324749cab8b24eea3572692c,

title = "Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach",

author = "M. Went and A. Sud and Law, {P. J.} and Johnson, {D. C.} and N. Weinhold and A. F{\"o}rsti and M. Duin and Mitchell, {J. S.} and B. Chen and R. Kuiper and Stephens, {O. W.} and U. Bertsch and C. Campo and H. Einsele and Gregory, {W. M.} and M. Henrion and J. Hillengass and P. Hoffmann and Jackson, {G. H.} and O. Lenive and J. Nickel and N{\"o}then, {M. M.} and Filho, {M. I.da Silva} and H. Thomsen and Walker, {B. A.} and A. Broyl and Davies, {F. E.} and C. Langer and M. Hansson and M. Kaiser and P. Sonneveld and H. Goldschmidt and K. Hemminki and B. Nilsson and Morgan, {G. J.} and Houlston, {R. S.}",

note = "Funding Information: In the United Kingdom, Myeloma UK and Bloodwise provided principal funding. Additional funding was provided by Cancer Research UK (C1298/A8362 supported by Funding Information: In the United Kingdom, Myeloma UK and Bloodwise provided principal funding. Additional funding was provided by Cancer Research UK (C1298/A8362 supported by the Bobby Moore Fund) and The Rosetrees Trust. This study made use of the genotyping data on the 1958 Birth Cohort generated by the Wellcome Trust Sanger Institute (http://www.wtccc.org.uk). We are grateful to all investigators who contributed to NSCCG and GELCAPS, from which controls in the replication were drawn. We also thank the staff of the CTRU University of Leeds and the NCRI Haematology Clinical Studies Group. The US GWAS was supported by a grant from the National Institutes of Health (P01CA055819). The German study was supported by the Dietmar-Hopp-Stiftung, Germany, the German Cancer Aid (110,131), the German Federal Ministry of Education and Research (CLIOMMICS 01ZX1309), the German Research Council (DFG; Project SI236/8-1, SI236/9-1, ER 155/6-1 and the DFG CRU 216) and the Multiple Myeloma Research Foundation. The patients were collected by the GMMG and DSMM studies. The German GWAS made use of the genotyping data from the population-based HNR study, which is supported by the Heinz Nixdorf Foundation (Germany). The genotyping of the Illumina HumanOmni-1 Quad BeadChips of the HNR subjects was financed by the German Center for Neurodegenerative Disorders (DZNE), Bonn, Germany. We are grateful to all investigators who contributed to the generation of this data set. The German replication controls were collected by Peter Bugert, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-W{\"u}rttemberg-Hessen, Mannheim, Germany. This work was supported by research grants from the Swedish Foundation for Strategic Research (KF10-0009), the Marianne and Marcus Wallenberg Foundation (2010.0112), the Knut and Alice Wallenberg Foundation (2012.0193), the Swedish Research Council (2012–1753), the Royal Swedish Academy of Science, ALF grants to the University and Regional Laboratories (Labmedicin Sk{\aa}ne), the Siv-Inger and Per-Erik Andersson Foundation, the Medical Faculty at Lund University and the Swedish Society of Medicine. We thank J{\"o}rgen Adolfsson, Tomas Axelsson, Anna Collin, Ildik{\'o} Frigyesi, Patrik Magnusson, Bertil Johansson, Jan Westin and Helga {\"O}gmundsd{\'o}ttir for their assistance. We are indebted to the clinicians who contributed samples to Swedish, Norwegian and Danish biobanks. We are indebted to the patients and other individuals who participated in the project. This work was supported by Center for Translational Molecular Medicine (BioCHIP), a clinical research grant from the European Hematology Association, an EMCR Translational Research Grant, a BMBF grant from CLIOMMICS (01ZX1309A) and FP7 grant MSCNET (LSHC-Ct-2006-037602). We thank the staff of the HOVON, as well as patients and physicians at participating sites. In addition, we also thank Jasper Koenders, Michael Vermeulen, Andr{\'e} Uitterlinden and Nathalie van der Velde for their assistance. Funding Information: the Bobby Moore Fund) and The Rosetrees Trust. This study made use of the genotyping data on the 1958 Birth Cohort generated by the Wellcome Trust Sanger Institute (http://www.wtccc.org.uk). We are grateful to all investigators who contributed to NSCCG and GELCAPS, from which controls in the replication were drawn. We also thank the staff of the CTRU University of Leeds and the NCRI Haematology Clinical Studies Group. The US GWAS was supported by a grant from the National Institutes of Health (P01CA055819). The German study was supported by the Dietmar-Hopp-Stiftung, Germany, the German Cancer Aid (110,131), the German Federal Ministry of Education and Research (CLIOMMICS 01ZX1309), the German Research Council (DFG; Project SI236/8-1, SI236/9-1, ER 155/6-1 and the DFG CRU 216) and the Multiple Myeloma Research Foundation. The patients were collected by the GMMG and DSMM studies. The German GWAS made use of the genotyping data from the population-based HNR study, which is supported by the Heinz Nixdorf Foundation (Germany). The genotyping of the Illumina HumanOmni-1 Quad BeadChips of the HNR subjects was financed by the German Center for Neurodegenerative Disorders (DZNE), Bonn, Germany. We are grateful to all investigators who contributed to the generation of this data set. The German replication controls were collected by Peter Bugert, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-W{\"u}rttemberg-Hessen, Mannheim, Germany. This work was supported by research grants from the Swedish Foundation for Strategic Research (KF10-0009), the Marianne and Marcus Wallenberg Foundation (2010.0112), the Knut and Alice Wallenberg Foundation (2012.0193), the Swedish Research Council (2012–1753), the Royal Swedish Academy of Science, ALF grants to the University and Regional Laboratories (Labmedicin Sk{\aa}ne), the Siv-Inger and Per-Erik Andersson Foundation, the Medical Faculty at Lund University and the Swedish Society of Medicine. We thank J{\"o}rgen Adolfsson, Tomas Axelsson, Anna Collin, Ildik{\'o} Frigyesi, Patrik Magnusson, Bertil Johansson, Jan Westin and Helga {\"O}gmundsd{\'o}ttir for their assistance. We are indebted to the clinicians who contributed samples to Swedish, Norwegian and Danish biobanks. We are indebted to the patients and other individuals who participated in the project. This work was supported by Center for Translational Molecular Medicine (BioCHIP), a clinical research grant from the European Hematology Association, an EMCR Translational Research Grant, a BMBF grant from CLIOMMICS (01ZX1309A) and FP7 grant MSCNET (LSHC-Ct-2006-037602). We thank the staff of the HOVON, as well as patients and physicians at participating sites. In addition, we also thank Jasper Koenders, Michael Vermeulen, Andr{\'e} Uitterlinden and Nathalie van der Velde for their assistance.",

year = "2017",

doi = "10.1038/BCJ.2017.48",

language = "English",

volume = "7",

journal = "Blood Cancer Journal",

issn = "2044-5385",

publisher = "Nature Publishing Group",

number = "6",

}

Went, M, Sud, A, Law, PJ, Johnson, DC, Weinhold, N, Försti, A, Duin, M, Mitchell, JS, Chen, B, Kuiper, R, Stephens, OW, Bertsch, U, Campo, C, Einsele, H, Gregory, WM, Henrion, M, Hillengass, J, Hoffmann, P, Jackson, GH, Lenive, O, Nickel, J, Nöthen, MM, Filho, MIDS, Thomsen, H, Walker, BA, Broyl, A, Davies, FE, Langer, C, Hansson, M, Kaiser, M, Sonneveld, P, Goldschmidt, H, Hemminki, K, Nilsson, B, Morgan, GJ & Houlston, RS 2017, 'Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach', Blood Cancer Journal, vol. 7, no. 6, e573. https://doi.org/10.1038/BCJ.2017.48

TY - JOUR

T1 - Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach

AU - Went, M.

AU - Sud, A.

AU - Law, P. J.

AU - Johnson, D. C.

AU - Weinhold, N.

AU - Försti, A.

AU - Duin, M.

AU - Mitchell, J. S.

AU - Chen, B.

AU - Kuiper, R.

AU - Stephens, O. W.

AU - Bertsch, U.

AU - Campo, C.

AU - Einsele, H.

AU - Gregory, W. M.

AU - Henrion, M.

AU - Hillengass, J.

AU - Hoffmann, P.

AU - Jackson, G. H.

AU - Lenive, O.

AU - Nickel, J.

AU - Nöthen, M. M.

AU - Filho, M. I.da Silva

AU - Thomsen, H.

AU - Walker, B. A.

AU - Broyl, A.

AU - Davies, F. E.

AU - Langer, C.

AU - Hansson, M.

AU - Kaiser, M.

AU - Sonneveld, P.

AU - Goldschmidt, H.

AU - Hemminki, K.

AU - Nilsson, B.

AU - Morgan, G. J.

AU - Houlston, R. S.

N1 - Funding Information: In the United Kingdom, Myeloma UK and Bloodwise provided principal funding. Additional funding was provided by Cancer Research UK (C1298/A8362 supported by Funding Information: In the United Kingdom, Myeloma UK and Bloodwise provided principal funding. Additional funding was provided by Cancer Research UK (C1298/A8362 supported by the Bobby Moore Fund) and The Rosetrees Trust. This study made use of the genotyping data on the 1958 Birth Cohort generated by the Wellcome Trust Sanger Institute (http://www.wtccc.org.uk). We are grateful to all investigators who contributed to NSCCG and GELCAPS, from which controls in the replication were drawn. We also thank the staff of the CTRU University of Leeds and the NCRI Haematology Clinical Studies Group. The US GWAS was supported by a grant from the National Institutes of Health (P01CA055819). The German study was supported by the Dietmar-Hopp-Stiftung, Germany, the German Cancer Aid (110,131), the German Federal Ministry of Education and Research (CLIOMMICS 01ZX1309), the German Research Council (DFG; Project SI236/8-1, SI236/9-1, ER 155/6-1 and the DFG CRU 216) and the Multiple Myeloma Research Foundation. The patients were collected by the GMMG and DSMM studies. The German GWAS made use of the genotyping data from the population-based HNR study, which is supported by the Heinz Nixdorf Foundation (Germany). The genotyping of the Illumina HumanOmni-1 Quad BeadChips of the HNR subjects was financed by the German Center for Neurodegenerative Disorders (DZNE), Bonn, Germany. We are grateful to all investigators who contributed to the generation of this data set. The German replication controls were collected by Peter Bugert, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany. This work was supported by research grants from the Swedish Foundation for Strategic Research (KF10-0009), the Marianne and Marcus Wallenberg Foundation (2010.0112), the Knut and Alice Wallenberg Foundation (2012.0193), the Swedish Research Council (2012–1753), the Royal Swedish Academy of Science, ALF grants to the University and Regional Laboratories (Labmedicin Skåne), the Siv-Inger and Per-Erik Andersson Foundation, the Medical Faculty at Lund University and the Swedish Society of Medicine. We thank Jörgen Adolfsson, Tomas Axelsson, Anna Collin, Ildikó Frigyesi, Patrik Magnusson, Bertil Johansson, Jan Westin and Helga Ögmundsdóttir for their assistance. We are indebted to the clinicians who contributed samples to Swedish, Norwegian and Danish biobanks. We are indebted to the patients and other individuals who participated in the project. This work was supported by Center for Translational Molecular Medicine (BioCHIP), a clinical research grant from the European Hematology Association, an EMCR Translational Research Grant, a BMBF grant from CLIOMMICS (01ZX1309A) and FP7 grant MSCNET (LSHC-Ct-2006-037602). We thank the staff of the HOVON, as well as patients and physicians at participating sites. In addition, we also thank Jasper Koenders, Michael Vermeulen, André Uitterlinden and Nathalie van der Velde for their assistance. Funding Information: the Bobby Moore Fund) and The Rosetrees Trust. This study made use of the genotyping data on the 1958 Birth Cohort generated by the Wellcome Trust Sanger Institute (http://www.wtccc.org.uk). We are grateful to all investigators who contributed to NSCCG and GELCAPS, from which controls in the replication were drawn. We also thank the staff of the CTRU University of Leeds and the NCRI Haematology Clinical Studies Group. The US GWAS was supported by a grant from the National Institutes of Health (P01CA055819). The German study was supported by the Dietmar-Hopp-Stiftung, Germany, the German Cancer Aid (110,131), the German Federal Ministry of Education and Research (CLIOMMICS 01ZX1309), the German Research Council (DFG; Project SI236/8-1, SI236/9-1, ER 155/6-1 and the DFG CRU 216) and the Multiple Myeloma Research Foundation. The patients were collected by the GMMG and DSMM studies. The German GWAS made use of the genotyping data from the population-based HNR study, which is supported by the Heinz Nixdorf Foundation (Germany). The genotyping of the Illumina HumanOmni-1 Quad BeadChips of the HNR subjects was financed by the German Center for Neurodegenerative Disorders (DZNE), Bonn, Germany. We are grateful to all investigators who contributed to the generation of this data set. The German replication controls were collected by Peter Bugert, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany. This work was supported by research grants from the Swedish Foundation for Strategic Research (KF10-0009), the Marianne and Marcus Wallenberg Foundation (2010.0112), the Knut and Alice Wallenberg Foundation (2012.0193), the Swedish Research Council (2012–1753), the Royal Swedish Academy of Science, ALF grants to the University and Regional Laboratories (Labmedicin Skåne), the Siv-Inger and Per-Erik Andersson Foundation, the Medical Faculty at Lund University and the Swedish Society of Medicine. We thank Jörgen Adolfsson, Tomas Axelsson, Anna Collin, Ildikó Frigyesi, Patrik Magnusson, Bertil Johansson, Jan Westin and Helga Ögmundsdóttir for their assistance. We are indebted to the clinicians who contributed samples to Swedish, Norwegian and Danish biobanks. We are indebted to the patients and other individuals who participated in the project. This work was supported by Center for Translational Molecular Medicine (BioCHIP), a clinical research grant from the European Hematology Association, an EMCR Translational Research Grant, a BMBF grant from CLIOMMICS (01ZX1309A) and FP7 grant MSCNET (LSHC-Ct-2006-037602). We thank the staff of the HOVON, as well as patients and physicians at participating sites. In addition, we also thank Jasper Koenders, Michael Vermeulen, André Uitterlinden and Nathalie van der Velde for their assistance.

PY - 2017

Y1 - 2017

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U2 - 10.1038/BCJ.2017.48

DO - 10.1038/BCJ.2017.48

M3 - Letter

C2 - 28622301

AN - SCOPUS:85052455531

SN - 2044-5385

VL - 7

JO - Blood Cancer Journal

JF - Blood Cancer Journal

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M1 - e573

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