Assessing motor development and function in mouse models of neurodevelopmental disorders

Lauren Dierdorff, Marta Garcia-Forn, Alexa von Mueffling, Silvia De Rubeis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Alterations in motor development often accompany neurodevelopmental disorders (NDD) and can have an impact on social interaction and communication. Studying motor development and function in mouse models of NDDs can offer a window to identify underlying biological mechanisms and establish preclinical outcome measures for testing therapeutics. This chapter describes tests to measure motor developmental milestones early postnatally and adult motor functions in mouse models of NDDs.

Original languageEnglish
Title of host publicationAnimal Models of Disease - Part B
PublisherAcademic Press Inc.
Pages171-181
Number of pages11
ISBN (Print)9780443222405
DOIs
StatePublished - Jan 2024

Publication series

NameMethods in Cell Biology
Volume188
ISSN (Print)0091-679X

Keywords

  • Motor function
  • Motor milestones
  • Neurodevelopment
  • Neurodevelopmental disorders
  • Preclinical outcome measures

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