Assessing left ventricular systolic dysfunction after myocardial infarction: Are ejection fraction and dP/dt max complementary or redundant?

Kiyotake Ishikawa, Elie R. Chemaly, Lisa Tilemann, Kenneth Fish, Dennis Ladage, Jaime Aguero, Torsten Vahl, Carlos Santos-Gallego, Yoshiaki Kawase, Roger J. Hajjar

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Among the various cardiac contractility parameters, left ventricular (LV) ejection fraction (EF) and maximum dP/dt (dP/dt max) are the simplest and most used. However, these parameters are often reported together, and it is not clear if they are complementary or redundant. We sought to compare the discriminative value of EF and dP/dt max in assessing systolic dysfunction after myocardial infarction (MI) in swine. A total of 220 measurements were obtained. All measurements included LV volumes and EF analysis by left ventriculography, invasive ventricular pressure tracings, and echocardiography. Baseline measurements were performed in 132 pigs, and 88 measurements were obtained at different time points after MI creation. Receiver operator characteristic (ROC) curves to distinguish the presence or absence of an MI revealed a good predictive value for EF [area under the curve (AUC): 0.998] but not by dP/dt max (AUC: 0.69, P < 0.001 vs. EF). Dividing dP/dt max by LV end-diastolic pressure and heart rate (HR) significantly increased the AUC to 0.87 (P < 0.001 vs. dP/dt max and P < 0.001 vs. EF). In naïve pigs, the coefficient of variation of dP/dt max was twice than that of EF (22.5% vs. 9.5%, respectively). Furthermore, in n = 19 pigs, dP/dt max increased after MI. However, echocardiographic strain analysis of 23 pigs with EF ranging only from 36% to 40% after MI revealed significant correlations between dP/dt max and strain parameters in the noninfarcted area (circumferential strain: r = 0.42, P = 0.05; radial strain: r = 0.71, P < 0.001). In conclusion, EF is a more accurate measure of systolic dysfunction than dP/dt max in a swine model of MI. Despite the variability of dP/dt max both in naïve pigs and after MI, it may sensitively reflect the small changes of myocardial contractility.

Original languageEnglish
Pages (from-to)H1423-H1428
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume302
Issue number7
DOIs
StatePublished - 1 Apr 2012

Keywords

  • Cardiac function
  • Contractility
  • Peak rate of the left ventricular pressure systolic increase over time
  • Pig
  • Receiver operater characteristic curves
  • Strain imaging

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