Arthritic and bone-softening diseases of the craniocervical junction

John S.C. Shiau, Marc S. Arginteanu, Noel I. Perin

Research output: Contribution to journalReview articlepeer-review


Rheumatoid arthritis and other bone-softening diseases such as Paget's disease, osteogenesis imperfecta, rickets, osteomalacia, and hyperparathyroidism have the potential to destabilize the upper cervical spine. In these disease settings, the relation between the occiput, axis, and atlas may be altered and destabilized. This paper reviews the anatomy, clinical presentation, and pathogenesis of the different diseases, as well as their medical and surgical management at the occipitocervical junction.

Original languageEnglish
Pages (from-to)180-190
Number of pages11
JournalNeurosurgery Quarterly
Issue number3
StatePublished - Sep 1998


  • Atlantoaxial
  • Bone-softening diseases
  • Fusion
  • Occipitocervical
  • Rheumatoid arthritis


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