ARFID Genes and Environment (ARFID-GEN): study protocol

Cynthia M. Bulik; Nadia Micali; Casey M. MacDermod; Baiyu Qi; Melissa A. Munn-Chernoff; Laura M. Thornton; Jennifer White; Lisa Dinkler; Emily M. Pisetsky; Jessica Johnson; Katelin R. Devine; Shelby N. Ortiz; Ava E. Silverman; Natasha Berthold; Alexis Dumain; Jerry Guintivano; Matthew Halvorsen; James J. Crowley

doi:10.1186/s12888-023-05266-x

ARFID Genes and Environment (ARFID-GEN): study protocol

Cynthia M. Bulik
, Nadia Micali
, Casey M. MacDermod
, Baiyu Qi
, Melissa A. Munn-Chernoff
, Laura M. Thornton
, Jennifer White
, Lisa Dinkler
, Emily M. Pisetsky
, Jessica Johnson
, Katelin R. Devine
, Shelby N. Ortiz
, Ava E. Silverman
, Natasha Berthold
, Alexis Dumain
, Jerry Guintivano
, Matthew Halvorsen
, James J. Crowley

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

Original language	English
Article number	863
Journal	BMC Psychiatry
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12888-023-05266-x
State	Published - Dec 2023
Externally published	Yes

Keywords

Avoidant restrictive food intake disorder
Eating disorders
Genome-wide association
Picky eating
Psychiatric genetics
Psychiatric genomics consortium
Selective eating
Social media

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10.1186/s12888-023-05266-x

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Bulik, C. M., Micali, N., MacDermod, C. M., Qi, B., Munn-Chernoff, M. A., Thornton, L. M., White, J., Dinkler, L., Pisetsky, E. M., Johnson, J., Devine, K. R., Ortiz, S. N., Silverman, A. E., Berthold, N., Dumain, A., Guintivano, J., Halvorsen, M., & Crowley, J. J. (2023). ARFID Genes and Environment (ARFID-GEN): study protocol. BMC Psychiatry, 23(1), Article 863. https://doi.org/10.1186/s12888-023-05266-x

@article{e989f9222f104438978ab3451ea55620,

title = "ARFID Genes and Environment (ARFID-GEN): study protocol",

abstract = "Background: The Avoidant Restrictive Food Intake Disorder {\textendash} Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver {\textquotedblleft}actionable{\textquotedblright} findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.",

keywords = "Avoidant restrictive food intake disorder, Eating disorders, Genome-wide association, Picky eating, Psychiatric genetics, Psychiatric genomics consortium, Selective eating, Social media",

author = "Bulik, \{Cynthia M.\} and Nadia Micali and MacDermod, \{Casey M.\} and Baiyu Qi and Munn-Chernoff, \{Melissa A.\} and Thornton, \{Laura M.\} and Jennifer White and Lisa Dinkler and Pisetsky, \{Emily M.\} and Jessica Johnson and Devine, \{Katelin R.\} and Ortiz, \{Shelby N.\} and Silverman, \{Ava E.\} and Natasha Berthold and Alexis Dumain and Jerry Guintivano and Matthew Halvorsen and Crowley, \{James J.\}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1186/s12888-023-05266-x",

language = "English",

volume = "23",

journal = "BMC Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central Ltd.",

number = "1",

}

Bulik, CM, Micali, N, MacDermod, CM, Qi, B, Munn-Chernoff, MA, Thornton, LM, White, J, Dinkler, L, Pisetsky, EM, Johnson, J, Devine, KR, Ortiz, SN, Silverman, AE, Berthold, N, Dumain, A, Guintivano, J, Halvorsen, M & Crowley, JJ 2023, 'ARFID Genes and Environment (ARFID-GEN): study protocol', BMC Psychiatry, vol. 23, no. 1, 863. https://doi.org/10.1186/s12888-023-05266-x

TY - JOUR

T1 - ARFID Genes and Environment (ARFID-GEN)

T2 - study protocol

AU - Bulik, Cynthia M.

AU - Micali, Nadia

AU - MacDermod, Casey M.

AU - Qi, Baiyu

AU - Munn-Chernoff, Melissa A.

AU - Thornton, Laura M.

AU - White, Jennifer

AU - Dinkler, Lisa

AU - Pisetsky, Emily M.

AU - Johnson, Jessica

AU - Devine, Katelin R.

AU - Ortiz, Shelby N.

AU - Silverman, Ava E.

AU - Berthold, Natasha

AU - Dumain, Alexis

AU - Guintivano, Jerry

AU - Halvorsen, Matthew

AU - Crowley, James J.

PY - 2023/12

Y1 - 2023/12

N2 - Background: The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

AB - Background: The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

KW - Avoidant restrictive food intake disorder

KW - Eating disorders

KW - Genome-wide association

KW - Picky eating

KW - Psychiatric genetics

KW - Psychiatric genomics consortium

KW - Selective eating

KW - Social media

UR - https://www.scopus.com/pages/publications/85177660081

U2 - 10.1186/s12888-023-05266-x

DO - 10.1186/s12888-023-05266-x

M3 - Article

C2 - 37990202

AN - SCOPUS:85177660081

SN - 1471-244X

VL - 23

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 863

ER -

ARFID Genes and Environment (ARFID-GEN): study protocol

Abstract

Keywords

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