Are changes in HLA Ags responsible for leukemia relapse after HLA-matched allogeneic hematopoietic SCT?

A. Hamdi, K. Cao, L. M. Poon, F. Aung, S. Kornblau, M. A. Fernandez Vina, R. E. Champlin, S. O. Ciurea

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Loss of heterozygosity (LOH) has been shown to be associated with leukemia relapse after haploidentical transplantation. Whether such changes are an important cause of relapse after HLA-matched transplantation remains unclear. We retrospectively HLA-typed leukemic blasts for 71 patients with AML/myelodysplastic syndrome obtained from stored samples, and the results were compared with those obtained at diagnosis and/or before the transplant. No LOH or any other changes in HLA Ag were found in any of the samples tested post transplant as compared with pretransplant specimens. One patient had LOH in HLA class I Ag (HLA-A,-B and -C); however, these changes were present in the pretransplant sample indicating that they occurred before the transplant. We concluded that, in contrast with haploidentical transplantation, HLA loss does not have a major role as a mechanism of relapse after allogeneic transplantation with a closely HLA-matched donor.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalBone Marrow Transplantation
Volume50
Issue number3
DOIs
StatePublished - 1 Mar 2015
Externally publishedYes

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