Arachidonic acid metabolism in polymorphonuclear leukocytes from patients with chronic granulomatous disease

D. M. Smith; C. E. Walsh; L. R. Dechatelet; M. Waite

doi:10.1128/iai.40.3.1230-1233.1983

Arachidonic acid metabolism in polymorphonuclear leukocytes from patients with chronic granulomatous disease

D. M. Smith, C. E. Walsh, L. R. Dechatelet, M. Waite

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Abstract

The effect of the calcium ionophore A23187 on the release and metabolism of [³H]arachidonic acid was examined in normal polymorphonuclear leukocytes and those obtained from patients with chronic granulomatous disease. The ionophore A23187 which stimulates oxidative metabolism in normal polymorphonuclear leukocytes was ineffective in increasing oxidative metabolism (chemiluminescence) in polymorphonuclear leukocytes from patients with chronic granulomatous disease. However, the ionophore A23187 stimulated the release of [³H]arachidonic acid from chronic granulomatous disease neutrophil phospholipids and stimulated its metabolism into hydroxyeicosatetraenoic acids and leukotrienes.

Original language	English
Pages (from-to)	1230-1233
Number of pages	4
Journal	Infection and Immunity
Volume	40
Issue number	3
DOIs	https://doi.org/10.1128/iai.40.3.1230-1233.1983
State	Published - 1983
Externally published	Yes

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10.1128/iai.40.3.1230-1233.1983

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abstract = "The effect of the calcium ionophore A23187 on the release and metabolism of [3H]arachidonic acid was examined in normal polymorphonuclear leukocytes and those obtained from patients with chronic granulomatous disease. The ionophore A23187 which stimulates oxidative metabolism in normal polymorphonuclear leukocytes was ineffective in increasing oxidative metabolism (chemiluminescence) in polymorphonuclear leukocytes from patients with chronic granulomatous disease. However, the ionophore A23187 stimulated the release of [3H]arachidonic acid from chronic granulomatous disease neutrophil phospholipids and stimulated its metabolism into hydroxyeicosatetraenoic acids and leukotrienes.",

author = "Smith, {D. M.} and Walsh, {C. E.} and Dechatelet, {L. R.} and M. Waite",

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AU - Smith, D. M.

AU - Walsh, C. E.

AU - Dechatelet, L. R.

AU - Waite, M.

PY - 1983

Y1 - 1983

N2 - The effect of the calcium ionophore A23187 on the release and metabolism of [3H]arachidonic acid was examined in normal polymorphonuclear leukocytes and those obtained from patients with chronic granulomatous disease. The ionophore A23187 which stimulates oxidative metabolism in normal polymorphonuclear leukocytes was ineffective in increasing oxidative metabolism (chemiluminescence) in polymorphonuclear leukocytes from patients with chronic granulomatous disease. However, the ionophore A23187 stimulated the release of [3H]arachidonic acid from chronic granulomatous disease neutrophil phospholipids and stimulated its metabolism into hydroxyeicosatetraenoic acids and leukotrienes.

AB - The effect of the calcium ionophore A23187 on the release and metabolism of [3H]arachidonic acid was examined in normal polymorphonuclear leukocytes and those obtained from patients with chronic granulomatous disease. The ionophore A23187 which stimulates oxidative metabolism in normal polymorphonuclear leukocytes was ineffective in increasing oxidative metabolism (chemiluminescence) in polymorphonuclear leukocytes from patients with chronic granulomatous disease. However, the ionophore A23187 stimulated the release of [3H]arachidonic acid from chronic granulomatous disease neutrophil phospholipids and stimulated its metabolism into hydroxyeicosatetraenoic acids and leukotrienes.

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U2 - 10.1128/iai.40.3.1230-1233.1983

DO - 10.1128/iai.40.3.1230-1233.1983

M3 - Article

C2 - 6406364

AN - SCOPUS:0020626094

SN - 0019-9567

VL - 40

SP - 1230

EP - 1233

JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Arachidonic acid metabolism in polymorphonuclear leukocytes from patients with chronic granulomatous disease

Abstract

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