Appropriate uses of human immunoglobulin in clinical practice

This report aims to delineate current recommendations for the use and dosage of immunoglobulin in the prophylaxis of viral and bacterial infections and in replacement of antibodies in immunodeficient patients. It is a further aim of this report to point out clearly those situations where immunoglobulin is not deemed to be useful or is contraindicated. Inappropriate use of this valuable material results in excessive and unnecessary costs for health services, carries some risk and is wasteful. This report also summarizes current knowledge on adverse reactions to immunoglobulin injection and those qualities which would be most desirable, if not essential, for safe and useful immunoglobulin preparations.