Approach to patients with impaired renal function

Eugenia Nikolsky, Roxana Mehran

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Coronary artery disease (CAD) is a frequent comorbidity and a common cause of mortality in patients with chronic renal insufficiency (CRI). The reasons are multifactorial and include highrisk demographic characteristics of patients with CRI; metabolic changes contributing to accelerated atherosclerosis (lipid and carbohydrate abnormalities, glucose intolerance, insulin resistance, secondary hyperparathyroidism, increased levels of homocystein, and carnitine deficiency); propensity to a hypercoagulable state (enhanced fibrinogen activity and platelet aggregation); specifics of hemodynamic changes (volume and pressure overload); anemia; and electrolyte disturbances as well as impaired pharmacokinetics and pharmacodynamics of medications.

Original languageEnglish
Title of host publicationProblem Oriented Approaches in Interventional Cardiology
PublisherCRC Press
Pages139-149
Number of pages11
ISBN (Electronic)9780203091838
ISBN (Print)9781841846316
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

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