Approach to patients with impaired renal function

Eugenia Nikolsky, Roxana Mehran

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Coronary artery disease (CAD) is a frequent comorbidity and a common cause of mortality in patients with chronic renal insufficiency (CRI). The reasons are multifactorial and include highrisk demographic characteristics of patients with CRI; metabolic changes contributing to accelerated atherosclerosis (lipid and carbohydrate abnormalities, glucose intolerance, insulin resistance, secondary hyperparathyroidism, increased levels of homocystein, and carnitine deficiency); propensity to a hypercoagulable state (enhanced fibrinogen activity and platelet aggregation); specifics of hemodynamic changes (volume and pressure overload); anemia; and electrolyte disturbances as well as impaired pharmacokinetics and pharmacodynamics of medications.

Original languageEnglish
Title of host publicationProblem Oriented Approaches in Interventional Cardiology
PublisherCRC Press
Number of pages11
ISBN (Electronic)9780203091838
ISBN (Print)9781841846316
StatePublished - 1 Jan 2007
Externally publishedYes


Dive into the research topics of 'Approach to patients with impaired renal function'. Together they form a unique fingerprint.

Cite this