Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide

Charles G. Zubrod; Marvin Schneiderman; Emil Frei; Clyde Brindley; G. Lennard Gold; Bruce Shnider; Raul Oviedo; John Gorman; Ralph Jones; Ulfar Jonsson; Jack Colsky; Thomas Chalmers; Bruce Ferguson; Margarida Dederick; James Holland; Oleg Selawry; William Regelson; Louis Lasagna; Albert H. Owens

doi:10.1016/0021-9681(60)90137-5

Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide

Charles G. Zubrod, Marvin Schneiderman, Emil Frei, Clyde Brindley, G. Lennard Gold, Bruce Shnider, Raul Oviedo, John Gorman, Ralph Jones, Ulfar Jonsson, Jack Colsky, Thomas Chalmers, Bruce Ferguson, Margarida Dederick, James Holland, Oleg Selawry, William Regelson, Louis Lasagna, Albert H. Owens

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Abstract

Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application of the principles involved are illustrated in a comparative study of triethylene thiophosphoramide and nitrogen mustard in cancer of the lung and breast, melanoma, and Hodgkin's disease. Neither drug was appreciably effective in cancer of the lung which had previously been irradiated or in melanoma. In cancer of the lung not previously irradiated and in cancer of the breast, 30 to 50 per cent reduction in tumor size occurred in 10 to 26 per cent of the patients. In Hodgkin's disease certain factors limit the completeness of the comparison, but it is possible to draw the tentative conclusion that thio-TEPA was less active than HN2 (in the doses used) in inducing remissions. The advantages and disadvantages of this type of trial are discussed and several suggestions are made for improved experimental design.

Original language	English
Pages (from-to)	7-33
Number of pages	27
Journal	Journal of Chronic Diseases
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/0021-9681(60)90137-5
State	Published - Jan 1960
Externally published	Yes

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Zubrod, C. G., Schneiderman, M., Frei, E., Brindley, C., Lennard Gold, G., Shnider, B., Oviedo, R., Gorman, J., Jones, R., Jonsson, U., Colsky, J., Chalmers, T., Ferguson, B., Dederick, M., Holland, J., Selawry, O., Regelson, W., Lasagna, L., & Owens, A. H. (1960). Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. Journal of Chronic Diseases, 11(1), 7-33. https://doi.org/10.1016/0021-9681(60)90137-5

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title = "Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide",

abstract = "Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application of the principles involved are illustrated in a comparative study of triethylene thiophosphoramide and nitrogen mustard in cancer of the lung and breast, melanoma, and Hodgkin's disease. Neither drug was appreciably effective in cancer of the lung which had previously been irradiated or in melanoma. In cancer of the lung not previously irradiated and in cancer of the breast, 30 to 50 per cent reduction in tumor size occurred in 10 to 26 per cent of the patients. In Hodgkin's disease certain factors limit the completeness of the comparison, but it is possible to draw the tentative conclusion that thio-TEPA was less active than HN2 (in the doses used) in inducing remissions. The advantages and disadvantages of this type of trial are discussed and several suggestions are made for improved experimental design.",

author = "Zubrod, {Charles G.} and Marvin Schneiderman and Emil Frei and Clyde Brindley and {Lennard Gold}, G. and Bruce Shnider and Raul Oviedo and John Gorman and Ralph Jones and Ulfar Jonsson and Jack Colsky and Thomas Chalmers and Bruce Ferguson and Margarida Dederick and James Holland and Oleg Selawry and William Regelson and Louis Lasagna and Owens, {Albert H.}",

year = "1960",

month = jan,

doi = "10.1016/0021-9681(60)90137-5",

language = "English",

volume = "11",

pages = "7--33",

journal = "Journal of Chronic Diseases",

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publisher = "Elsevier USA",

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}

Zubrod, CG, Schneiderman, M, Frei, E, Brindley, C, Lennard Gold, G, Shnider, B, Oviedo, R, Gorman, J, Jones, R, Jonsson, U, Colsky, J, Chalmers, T, Ferguson, B, Dederick, M, Holland, J, Selawry, O, Regelson, W, Lasagna, L & Owens, AH 1960, 'Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide', Journal of Chronic Diseases, vol. 11, no. 1, pp. 7-33. https://doi.org/10.1016/0021-9681(60)90137-5

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T1 - Appraisal of methods for the study of chemotherapy of cancer in man

T2 - Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide

AU - Zubrod, Charles G.

AU - Schneiderman, Marvin

AU - Frei, Emil

AU - Brindley, Clyde

AU - Lennard Gold, G.

AU - Shnider, Bruce

AU - Oviedo, Raul

AU - Gorman, John

AU - Jones, Ralph

AU - Jonsson, Ulfar

AU - Colsky, Jack

AU - Chalmers, Thomas

AU - Ferguson, Bruce

AU - Dederick, Margarida

AU - Holland, James

AU - Selawry, Oleg

AU - Regelson, William

AU - Lasagna, Louis

AU - Owens, Albert H.

PY - 1960/1

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N2 - Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application of the principles involved are illustrated in a comparative study of triethylene thiophosphoramide and nitrogen mustard in cancer of the lung and breast, melanoma, and Hodgkin's disease. Neither drug was appreciably effective in cancer of the lung which had previously been irradiated or in melanoma. In cancer of the lung not previously irradiated and in cancer of the breast, 30 to 50 per cent reduction in tumor size occurred in 10 to 26 per cent of the patients. In Hodgkin's disease certain factors limit the completeness of the comparison, but it is possible to draw the tentative conclusion that thio-TEPA was less active than HN2 (in the doses used) in inducing remissions. The advantages and disadvantages of this type of trial are discussed and several suggestions are made for improved experimental design.

AB - Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application of the principles involved are illustrated in a comparative study of triethylene thiophosphoramide and nitrogen mustard in cancer of the lung and breast, melanoma, and Hodgkin's disease. Neither drug was appreciably effective in cancer of the lung which had previously been irradiated or in melanoma. In cancer of the lung not previously irradiated and in cancer of the breast, 30 to 50 per cent reduction in tumor size occurred in 10 to 26 per cent of the patients. In Hodgkin's disease certain factors limit the completeness of the comparison, but it is possible to draw the tentative conclusion that thio-TEPA was less active than HN2 (in the doses used) in inducing remissions. The advantages and disadvantages of this type of trial are discussed and several suggestions are made for improved experimental design.

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Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide

Abstract

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