Application of Single-Cell Sequencing to Immunotherapy

Kristin G. Beaumont, Michael A. Beaumont, Robert Sebra

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Cancer is a highly complex and heterogeneous disease and immunotherapy has shown promise as a therapeutic approach. The increased resolution afforded by single-cell analysis offers the hope of finding and characterizing previously underappreciated populations of cells that could prove useful in understanding cancer progression and treatment. Urologic and prostate cancers are inherently heterogeneous diseases, and the potential for single-cell analysis to help understand and develop immunotherapeutic approaches to treat these diseases is very exciting. In this review, we view cancer immunotherapy through a single-cell lens and discuss the state-of-the-art technologies that enable advances in this field.

Original languageEnglish
Pages (from-to)475-485
Number of pages11
JournalUrologic Clinics of North America
Issue number4
StatePublished - Nov 2020


  • Cancer
  • Immunotherapy
  • Prostate cancer
  • Single-cell analysis
  • Tumor heterogeneity
  • Urologic cancer


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