Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value

Bryan Williams, Patrick Brunel, Peter S. Lacy, Fabio Baschiera, Dion H. Zappe, Kazuomi Kario, John Cockcroft

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalArtery Research
Volume17
DOIs
StatePublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Applanation tonometry
  • Arterial stiffness
  • Central aortic pressure
  • Clinical outcomes
  • Hemodynamics
  • Pulse waveform analysis
  • Wave reflection

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