Application of Antioxidant Compounds in Bone Defect Repair

Jiajia Wang; Yubing Zhang; Qingming Tang; Yinan Zhang; Ying Yin; Lili Chen

doi:10.3390/antiox13070789

Application of Antioxidant Compounds in Bone Defect Repair

Jiajia Wang
, Yubing Zhang
, Qingming Tang
, Yinan Zhang
, Ying Yin
, Lili Chen

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.

Original language	English
Article number	789
Journal	Antioxidants
Volume	13
Issue number	7
DOIs	https://doi.org/10.3390/antiox13070789
State	Published - Jul 2024
Externally published	Yes

Keywords

ROS
antioxidant compounds
biomaterials
bone defect

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10.3390/antiox13070789

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title = "Application of Antioxidant Compounds in Bone Defect Repair",

abstract = "Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.",

keywords = "ROS, antioxidant compounds, biomaterials, bone defect",

author = "Jiajia Wang and Yubing Zhang and Qingming Tang and Yinan Zhang and Ying Yin and Lili Chen",

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year = "2024",

month = jul,

doi = "10.3390/antiox13070789",

language = "English",

volume = "13",

journal = "Antioxidants",

issn = "2076-3921",

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}

TY - JOUR

T1 - Application of Antioxidant Compounds in Bone Defect Repair

AU - Wang, Jiajia

AU - Zhang, Yubing

AU - Tang, Qingming

AU - Zhang, Yinan

AU - Yin, Ying

AU - Chen, Lili

PY - 2024/7

Y1 - 2024/7

N2 - Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.

AB - Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.

KW - ROS

KW - antioxidant compounds

KW - biomaterials

KW - bone defect

UR - https://www.scopus.com/pages/publications/85199652934

U2 - 10.3390/antiox13070789

DO - 10.3390/antiox13070789

M3 - Review article

AN - SCOPUS:85199652934

SN - 2076-3921

VL - 13

JO - Antioxidants

JF - Antioxidants

IS - 7

M1 - 789

ER -

Application of Antioxidant Compounds in Bone Defect Repair

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Keywords

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