APP substitutions V715F and L720P alter PS1 conformation and differentially affect Aβ and AICD generation

Keyphrases

• Amyloid Precursor Protein 100%
• Presenilin 100%
• Protein Substitution 100%
• Domain Generation 100%
• APP Intracellular Domain 100%
• Secretase 60%
• In Vitro Generation 40%
• Alzheimer's Disease Brain 20%
• Amino Acids 20%
• Transmembrane Domain 20%
• Catalytic Site 20%
• C-terminus 20%
• Proteolysis 20%
• Amyloid Deposition 20%
• Differential Effects 20%
• N-terminus 20%
• Amino Acid Substitution 20%
• Single-molecule Fluorescence Resonance Energy Transfer (smFRET) 20%
• Transfer Method 20%
• Amyloid Precursor Protein Intracellular Domain 20%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Amyloid Precursor Protein 100%
• Presenilin 100%
• Secretase 60%
• N-Terminus 20%
• C-Terminus 20%
• Transmembrane Domain 20%
• Amino Acids 20%
• Amino Acid Substitution 20%
• Fluorescence Resonance Energy Transfer 20%
• Amyloid Protein 20%
• Proteolysis 20%

Immunology and Microbiology

• Precursor 100%
• Conformation 100%
• In Vitro 40%
• Amino Terminal Sequence 20%
• Carboxy Terminal Sequence 20%
• Protein Degradation 20%
• Energy Transfer 20%
• Amino Acid Substitution 20%
• Peptides 20%
• Amino Acid 20%