Apoptotic cells at the crossroads of tolerance and immunity

M. Škoberne, A. S. Beignon, M. Larsson, N. Bhardwaj

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place. Preferential ligation of specific receptors on professional antigen-presenting cells (dendritic cells) has been proposed to induce potentially tolerogenic signals. On the other hand, dendritic cells can efficiently process and present antigens from pathogen-infected apoptotic cells to T cells. In this review, we discuss how apoptotic cells manipulate immunity through interactions with dendritic cells.

Original languageEnglish
Pages (from-to)259-292
Number of pages34
JournalCurrent Topics in Microbiology and Immunology
Volume289
DOIs
StatePublished - 2005
Externally publishedYes

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