Apolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers

Niralee Patel; Girish N. Nadkarni

doi:10.1016/j.ccl.2019.04.009

Apolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers

Niralee Patel, Girish N. Nadkarni

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on chromosome 22 seen only in individuals of recent African ancestry explains a large proportion of kidney disease disparities. In addition, recent large-scale genotype-phenotype association studies have identified associations with cardiovascular disease and hypertension. This review aims to review the recent literature in this field and point toward future directions for research.

Original language	English
Pages (from-to)	327-334
Number of pages	8
Journal	Cardiology Clinics
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.ccl.2019.04.009
State	Published - Aug 2019

Keywords

Cardiovascular disease
Hypertension
Kidney disease

Access to Document

10.1016/j.ccl.2019.04.009

Cite this

@article{8e7fcf7b2c39403fa39b44e552c96f31,

title = "Apolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers",

abstract = "Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on chromosome 22 seen only in individuals of recent African ancestry explains a large proportion of kidney disease disparities. In addition, recent large-scale genotype-phenotype association studies have identified associations with cardiovascular disease and hypertension. This review aims to review the recent literature in this field and point toward future directions for research.",

keywords = "Cardiovascular disease, Hypertension, Kidney disease",

author = "Niralee Patel and Nadkarni, {Girish N.}",

note = "Funding Information: Disclosure statement: Dr G.N. Nadkarni is supported by a career development award from the National Institutes of Health (NIH) (K23DK107908) and is also supported by R01DK108803, U01HG007278, U01HG009610, and 1U01DK116100. The remaining authors have nothing to disclose. Disclosure statement: Dr G.N. Nadkarni is supported by a career development award from the National Institutes of Health (NIH) ( K23DK107908) and is also supported by R01DK108803, U01HG007278, U01HG009610, and 1U01DK116100. The remaining authors have nothing to disclose. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

doi = "10.1016/j.ccl.2019.04.009",

language = "English",

volume = "37",

pages = "327--334",

journal = "Cardiology Clinics",

issn = "0733-8651",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Apolipoprotein L1, Cardiovascular Disease and Hypertension

T2 - More Questions than Answers

AU - Patel, Niralee

AU - Nadkarni, Girish N.

N1 - Funding Information: Disclosure statement: Dr G.N. Nadkarni is supported by a career development award from the National Institutes of Health (NIH) (K23DK107908) and is also supported by R01DK108803, U01HG007278, U01HG009610, and 1U01DK116100. The remaining authors have nothing to disclose. Disclosure statement: Dr G.N. Nadkarni is supported by a career development award from the National Institutes of Health (NIH) ( K23DK107908) and is also supported by R01DK108803, U01HG007278, U01HG009610, and 1U01DK116100. The remaining authors have nothing to disclose. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/8

Y1 - 2019/8

N2 - Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on chromosome 22 seen only in individuals of recent African ancestry explains a large proportion of kidney disease disparities. In addition, recent large-scale genotype-phenotype association studies have identified associations with cardiovascular disease and hypertension. This review aims to review the recent literature in this field and point toward future directions for research.

AB - Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on chromosome 22 seen only in individuals of recent African ancestry explains a large proportion of kidney disease disparities. In addition, recent large-scale genotype-phenotype association studies have identified associations with cardiovascular disease and hypertension. This review aims to review the recent literature in this field and point toward future directions for research.

KW - Cardiovascular disease

KW - Hypertension

KW - Kidney disease

UR - http://www.scopus.com/inward/record.url?scp=85065523048&partnerID=8YFLogxK

U2 - 10.1016/j.ccl.2019.04.009

DO - 10.1016/j.ccl.2019.04.009

M3 - Review article

C2 - 31279426

AN - SCOPUS:85065523048

SN - 0733-8651

VL - 37

SP - 327

EP - 334

JO - Cardiology Clinics

JF - Cardiology Clinics

IS - 3

ER -

Apolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers

Abstract

Keywords

Access to Document

Fingerprint

Cite this