Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

Mirella Salvatore; Angela Claudia Seeber; Benedetta Nacmias; Rosella Petraroli; Marco D'Alessandro; Sandro Sorbi; Maurizio Pocchiari

doi:10.1016/0304-3940(95)12030-8

Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

Mirella Salvatore
, Angela Claudia Seeber
, Benedetta Nacmias
, Rosella Petraroli
, Marco D'Alessandro
, Sandro Sorbi
, Maurizio Pocchiari

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	Neuroscience Letters
Volume	199
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)12030-8
State	Published - 20 Oct 1995
Externally published	Yes

Keywords

Allele frequency
Apolipoprotein E
Creutzfeldt-Jakob disease
Genotype distribution
PRNP

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10.1016/0304-3940(95)12030-8

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@article{5c72e63feb954e0eb223c69149f63a34,

title = "Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease",

abstract = "We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.",

keywords = "Allele frequency, Apolipoprotein E, Creutzfeldt-Jakob disease, Genotype distribution, PRNP",

author = "Mirella Salvatore and Seeber, \{Angela Claudia\} and Benedetta Nacmias and Rosella Petraroli and Marco D'Alessandro and Sandro Sorbi and Maurizio Pocchiari",

note = "Funding Information: We thank Prof. Giorgio Macchi and Dr. Maurizio Genuardi for helpful discussion and Ms. Deborah Wool for editorial assistance. This work was partially supported by the National Registry of Creutzfeldt-Jakob disease, financed by the Italian Ministry of Health-Istituto Superi-ore di Sanid and by Italian National Research Council (CNR) Target Project on Aging (Grant no. 952608). BN was also supported by Telethon Italia (no. E.304).",

year = "1995",

month = oct,

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doi = "10.1016/0304-3940(95)12030-8",

language = "English",

volume = "199",

pages = "95--98",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

AU - Salvatore, Mirella

AU - Seeber, Angela Claudia

AU - Nacmias, Benedetta

AU - Petraroli, Rosella

AU - D'Alessandro, Marco

AU - Sorbi, Sandro

AU - Pocchiari, Maurizio

N1 - Funding Information: We thank Prof. Giorgio Macchi and Dr. Maurizio Genuardi for helpful discussion and Ms. Deborah Wool for editorial assistance. This work was partially supported by the National Registry of Creutzfeldt-Jakob disease, financed by the Italian Ministry of Health-Istituto Superi-ore di Sanid and by Italian National Research Council (CNR) Target Project on Aging (Grant no. 952608). BN was also supported by Telethon Italia (no. E.304).

PY - 1995/10/20

Y1 - 1995/10/20

N2 - We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

AB - We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

KW - Allele frequency

KW - Apolipoprotein E

KW - Creutzfeldt-Jakob disease

KW - Genotype distribution

KW - PRNP

UR - https://www.scopus.com/pages/publications/0028849971

U2 - 10.1016/0304-3940(95)12030-8

DO - 10.1016/0304-3940(95)12030-8

M3 - Article

C2 - 8584252

AN - SCOPUS:0028849971

SN - 0304-3940

VL - 199

SP - 95

EP - 98

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

Abstract

Keywords

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