Aph-2/Nicastrin: An essential component of γ-secretase and regulator of Notch signaling and Presenilin localization

Raphael Kopan, Alison Goate

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations

Abstract

The Notch signaling pathway plays a role in cell fate specification in many metazoans. A critical aspect of Notch activation involves proteolysis of the Notch receptor. This cleavage event requires Presenilin as a component of a large multiprotein complex, γ-secretase. This complex mediates a similar cleavage event of the β-amyloid precursor protein (APP). The transmembrane protein Nicastrin has been found to associate with Presenilin, Notch, and APP. Recent biochemical and genetic studies have focused on elucidating the function of this protein.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalNeuron
Volume33
Issue number3
DOIs
StatePublished - 31 Jan 2002
Externally publishedYes

Fingerprint

Dive into the research topics of 'Aph-2/Nicastrin: An essential component of γ-secretase and regulator of Notch signaling and Presenilin localization'. Together they form a unique fingerprint.

Cite this